Abstract
Reactivity of leukocytes to allogeneic extracts of malignant prostate from patients with prostatic cancer, as evaluated by antigen-induced leukocyte-adherence inhibition, was significantly suppressed in the presence of diethylstilbestrol diphosphate. The observed suppression of tumor-associated immunity in the presence of exogenous estrogen provides further evidence supporting earlier studies that demonstrated estrogenic suppression of nonspecific cellular responsiveness, as evaluated by phytohemagglutinin-induced lymphocytic blastogenesis, and for the initially suggested concern over the efficacy of estrogenic therapy and its adverse effect on host cell-mediated immunologic responsiveness.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9-11 |
| Number of pages | 3 |
| Journal | Israel journal of medical sciences |
| Volume | 15 |
| Issue number | 1 |
| State | Published - 1979 |
| Externally published | Yes |
ASJC Scopus subject areas
- Bioengineering