Reactivity of leukocytes to allogeneic extracts of malignant prostate from patients with prostatic cancer, as evaluated by antigen-induced leukocyte-adherence inhibition, was significantly suppressed in the presence of diethylstilbestrol diphosphate. The observed suppression of tumor-associated immunity in the presence of exogenous estrogen provides further evidence supporting earlier studies that demonstrated estrogenic suppression of nonspecific cellular responsiveness, as evaluated by phytohemagglutinin-induced lymphocytic blastogenesis, and for the initially suggested concern over the efficacy of estrogenic therapy and its adverse effect on host cell-mediated immunologic responsiveness.
|Number of pages
|Israel journal of medical sciences
|Published - 1979
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