Abstract
Dehydroabietic acid (DHA) (1) is one of the main compounds in Scots pine wood responsible for aquatic and microbial toxicity. The degradation of 1 by Trametes versicolor and Phlebiopsis gigantea in liquid stationary cultures was followed by HPLC-DAD-ELSD. Both fungi rapidly degraded DHA relative to a control. More breakdown products were observed for T. versicolor than for P. gigantea. After 13 days, four compounds were identified by means of spectroscopic methods in P. gigantea cultures: 1β-hydroxy-DHA (2), 1β,7α-dihydroxy-DHA (3), 1β,16-dihydroxy-DHA (5), and tentatively 1β-hydroxy-7-oxo-DHA (4). In T. versicolor cultures, 1β,16-dihydroxy-DHA (5), 7β,16-dihydroxy-DHA (6), 1β,7β,16- trihydroxy-DHA (7), 1β,16-dihydroxy-7-oxo-DHA (8), 1β,15-dihydroxy-DHA (9), and 1β,7α,16-trihydroxy-DHA (10) were identified after 9 days of incubation. Thus the biotransformation of 1 by the two fungi was different, with only 5 being produced by both strains. Compounds 3, 7, 8, and 10 are reported for the first time as natural products.
Original language | English (US) |
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Pages (from-to) | 154-159 |
Number of pages | 6 |
Journal | Journal Of Natural Products |
Volume | 70 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2007 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry