@article{5b5883071e1a49e898f81f4fbaa47e19,
title = "Functionalized Spiroindolines with Anticancer Activity through a Metal-Free Post-Ugi Diastereoselective One-Pot Cascade Reaction",
abstract = "A post-Ugi diastereoselective one-pot cascade reaction requiring no metal catalyst was developed. The reaction scope was wide with mild conditions and good yields. A collection of spiroindolines was prepared by the protocol and screening tests in several difficult-to-inhibit cancer cell lines were conducted. The relationship of structure and anticancer activities was promising and in the Huh7 cell lines compound 16 j is more potent than Vinbalstine. The cyclization design strategy could be applicable to other multicomponent reactions (MCRs) for synthesizing bioactive and drug-like heterocycles.",
keywords = "Ugi reaction, cyclization reactions, multicomponent reactions, spiroindolines, synthetic methods",
author = "Xu, {Zhi Gang} and Li, {Shi Qiang} and Meng, {Jiang Ping} and Tang, {Dian Yong} and He, {Liu Jun} and Jie Lei and Lin, {Hui Kuan} and Li, {Hong Yu} and Chen, {Zhong Zhu}",
note = "Funding Information: The authors would like to thank the Chongqing Research Program of Basic Research and Frontier Technology (cstc2015jcy-jA1328, cstc2015zdcy-ztzx0191 and cstc2015zdcy-ztzx120003), Chongqing Education commission Project of China (KJZH17129) and the Scientific Research Foundation of the Chongqing University of Arts and Sciences (R2013XY01, R2013XY02 and Z2016BX02). H.L. was supported by the grants NIH R01 CA182424 and R01 CA193813. The authors would also like to thank Ms. H. Z. Liu for obtaining the LC/MS and NMR data. Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = may,
day = "7",
doi = "10.1002/chem.201801081",
language = "English (US)",
volume = "24",
pages = "6732--6736",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "26",
}