Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke

Lisa M. Jacola; M. B. Schapiro; V. J. Schmithorst; A. W. Byars; R. H. Strawsburg; J. P. Szaflarski; E. Plante; S. K. Holland

doi:10.1055/s-2006-923934

Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke

Lisa M. Jacola
, M. B. Schapiro
, V. J. Schmithorst
, A. W. Byars
, R. H. Strawsburg
, J. P. Szaflarski
, E. Plante
, S. K. Holland

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

We used verb generation and story listening tasks during fMRI to study language organization in children (7, 9 and 12 years old) with perinatal left MCA infarctions. Healthy, age-matched comparison children (n = 39) showed activation in left Broca's area during the verb generation task; in contrast, stroke subjects showed activation either bilaterally or in the right hemisphere homologue during both tasks. In Wernicke's area, comparison subjects showed left lateralization (verb generation) and bilateral activation (L > R) (story listening). Stroke subjects instead showed bilateral or right lateralization (verb generation) and bilateral activation (R > L) (story listening). Language is distributed atypically in children with perinatal left hemisphere stroke.

Original language	English (US)
Pages (from-to)	46-52
Number of pages	7
Journal	Neuropediatrics
Volume	37
Issue number	1
DOIs	https://doi.org/10.1055/s-2006-923934
State	Published - Feb 2006

Keywords

Language
Plasticity
Reorganization
Stroke
fMRI

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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10.1055/s-2006-923934

Cite this

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title = "Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke",

abstract = "We used verb generation and story listening tasks during fMRI to study language organization in children (7, 9 and 12 years old) with perinatal left MCA infarctions. Healthy, age-matched comparison children (n = 39) showed activation in left Broca's area during the verb generation task; in contrast, stroke subjects showed activation either bilaterally or in the right hemisphere homologue during both tasks. In Wernicke's area, comparison subjects showed left lateralization (verb generation) and bilateral activation (L > R) (story listening). Stroke subjects instead showed bilateral or right lateralization (verb generation) and bilateral activation (R > L) (story listening). Language is distributed atypically in children with perinatal left hemisphere stroke.",

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AU - Jacola, Lisa M.

AU - Schapiro, M. B.

AU - Schmithorst, V. J.

AU - Byars, A. W.

AU - Strawsburg, R. H.

AU - Szaflarski, J. P.

AU - Plante, E.

AU - Holland, S. K.

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AB - We used verb generation and story listening tasks during fMRI to study language organization in children (7, 9 and 12 years old) with perinatal left MCA infarctions. Healthy, age-matched comparison children (n = 39) showed activation in left Broca's area during the verb generation task; in contrast, stroke subjects showed activation either bilaterally or in the right hemisphere homologue during both tasks. In Wernicke's area, comparison subjects showed left lateralization (verb generation) and bilateral activation (L > R) (story listening). Stroke subjects instead showed bilateral or right lateralization (verb generation) and bilateral activation (R > L) (story listening). Language is distributed atypically in children with perinatal left hemisphere stroke.

KW - Language

KW - Plasticity

KW - Reorganization

KW - Stroke

KW - fMRI

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Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke

Abstract

Keywords

ASJC Scopus subject areas

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