Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke

Lisa M. Jacola; M. B. Schapiro; V. J. Schmithorst; A. W. Byars; R. H. Strawsburg; J. P. Szaflarski; E. Plante; S. K. Holland

doi:10.1055/s-2006-923934

Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke

Lisa M. Jacola, M. B. Schapiro, V. J. Schmithorst, A. W. Byars, R. H. Strawsburg, J. P. Szaflarski, E. Plante, S. K. Holland

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59 Scopus citations

Abstract

We used verb generation and story listening tasks during fMRI to study language organization in children (7, 9 and 12 years old) with perinatal left MCA infarctions. Healthy, age-matched comparison children (n = 39) showed activation in left Broca's area during the verb generation task; in contrast, stroke subjects showed activation either bilaterally or in the right hemisphere homologue during both tasks. In Wernicke's area, comparison subjects showed left lateralization (verb generation) and bilateral activation (L > R) (story listening). Stroke subjects instead showed bilateral or right lateralization (verb generation) and bilateral activation (R > L) (story listening). Language is distributed atypically in children with perinatal left hemisphere stroke.

Original language	English (US)
Pages (from-to)	46-52
Number of pages	7
Journal	Neuropediatrics
Volume	37
Issue number	1
DOIs	https://doi.org/10.1055/s-2006-923934
State	Published - Feb 2006

Keywords

Language
Plasticity
Reorganization
Stroke
fMRI

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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10.1055/s-2006-923934

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title = "Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke",

abstract = "We used verb generation and story listening tasks during fMRI to study language organization in children (7, 9 and 12 years old) with perinatal left MCA infarctions. Healthy, age-matched comparison children (n = 39) showed activation in left Broca's area during the verb generation task; in contrast, stroke subjects showed activation either bilaterally or in the right hemisphere homologue during both tasks. In Wernicke's area, comparison subjects showed left lateralization (verb generation) and bilateral activation (L > R) (story listening). Stroke subjects instead showed bilateral or right lateralization (verb generation) and bilateral activation (R > L) (story listening). Language is distributed atypically in children with perinatal left hemisphere stroke.",

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AU - Byars, A. W.

AU - Strawsburg, R. H.

AU - Szaflarski, J. P.

AU - Plante, E.

AU - Holland, S. K.

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AB - We used verb generation and story listening tasks during fMRI to study language organization in children (7, 9 and 12 years old) with perinatal left MCA infarctions. Healthy, age-matched comparison children (n = 39) showed activation in left Broca's area during the verb generation task; in contrast, stroke subjects showed activation either bilaterally or in the right hemisphere homologue during both tasks. In Wernicke's area, comparison subjects showed left lateralization (verb generation) and bilateral activation (L > R) (story listening). Stroke subjects instead showed bilateral or right lateralization (verb generation) and bilateral activation (R > L) (story listening). Language is distributed atypically in children with perinatal left hemisphere stroke.

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KW - Reorganization

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Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke

Abstract

Keywords

ASJC Scopus subject areas

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