TY - GEN
T1 - Functional interactions between opioid mu and delta receptors in vivo
AU - Porreca, F.
PY - 1990
Y1 - 1990
N2 - Recent work has shown that δ agonists, given at dose which do not produce antinociception, increase or decrease the antinociceptive potency and efficacy of some μ agonists such as morphine without altering the rate of development of tolerance. Such studies in vivo, and others in vitro, form the basis of a hypothesis of functionally complexed μ and δ receptors. Compounds with apparent selectivity for these sites are being identified.
AB - Recent work has shown that δ agonists, given at dose which do not produce antinociception, increase or decrease the antinociceptive potency and efficacy of some μ agonists such as morphine without altering the rate of development of tolerance. Such studies in vivo, and others in vitro, form the basis of a hypothesis of functionally complexed μ and δ receptors. Compounds with apparent selectivity for these sites are being identified.
UR - http://www.scopus.com/inward/record.url?scp=0025185611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025185611&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:0025185611
SN - 044481213X
T3 - New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914
SP - 280
BT - New leads in opioid research
A2 - Van Ree, J.M.
A2 - Mulder, A.H.
A2 - Wiegant, V.M.
A2 - Van Wimersma Greidanus, T.B.
A2 - Van Ree, J.M.
A2 - Mulder, A.H.
A2 - Wiegant, V.M.
A2 - Van Wimersma Greidanus, T.B.
PB - Elsevier Science Publishers B.V.
T2 - The International Narcotics Research Conference
Y2 - 8 July 1989 through 13 July 1989
ER -