Functional impairment of CD4 T cells despite normalization of T cell number in HIV

Kenneth S. Knox; Richard B. Day; Lisa M. Kohli; Chadi A. Hage; Homer L. Twigg

doi:10.1016/j.cellimm.2006.09.003

Functional impairment of CD4 T cells despite normalization of T cell number in HIV

Kenneth S. Knox, Richard B. Day, Lisa M. Kohli, Chadi A. Hage, Homer L. Twigg

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Using an in vitro model, we demonstrate that when CD4 T cells from HIV infected subjects are enriched from total blood lymphocytes the immune response to antigen is augmented. However, augmentation of this response is confined to HIV infected subjects with relatively preserved CD4 T cell counts. Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects.

Original language	English (US)
Pages (from-to)	46-51
Number of pages	6
Journal	Cellular Immunology
Volume	242
Issue number	1
DOIs	https://doi.org/10.1016/j.cellimm.2006.09.003
State	Published - Jul 2006
Externally published	Yes

Keywords

CD4
HIV
Lymphocyte
Memory
Mumps
Proliferation
Tetanus

ASJC Scopus subject areas

Immunology

Access to Document

10.1016/j.cellimm.2006.09.003

Cite this

@article{a700a8edd3e04f38933259c3a7dc4bf4,

title = "Functional impairment of CD4 T cells despite normalization of T cell number in HIV",

abstract = "Using an in vitro model, we demonstrate that when CD4 T cells from HIV infected subjects are enriched from total blood lymphocytes the immune response to antigen is augmented. However, augmentation of this response is confined to HIV infected subjects with relatively preserved CD4 T cell counts. Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects.",

keywords = "CD4, HIV, Lymphocyte, Memory, Mumps, Proliferation, Tetanus",

author = "Knox, {Kenneth S.} and Day, {Richard B.} and Kohli, {Lisa M.} and Hage, {Chadi A.} and Twigg, {Homer L.}",

note = "Funding Information: We thank Yana Wang for her technical support. Supported by HL04545 to K.S. Knox and HL59834 to H.L Twigg.",

year = "2006",

month = jul,

doi = "10.1016/j.cellimm.2006.09.003",

language = "English (US)",

volume = "242",

pages = "46--51",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Functional impairment of CD4 T cells despite normalization of T cell number in HIV

AU - Knox, Kenneth S.

AU - Day, Richard B.

AU - Kohli, Lisa M.

AU - Hage, Chadi A.

AU - Twigg, Homer L.

N1 - Funding Information: We thank Yana Wang for her technical support. Supported by HL04545 to K.S. Knox and HL59834 to H.L Twigg.

PY - 2006/7

Y1 - 2006/7

N2 - Using an in vitro model, we demonstrate that when CD4 T cells from HIV infected subjects are enriched from total blood lymphocytes the immune response to antigen is augmented. However, augmentation of this response is confined to HIV infected subjects with relatively preserved CD4 T cell counts. Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects.

AB - Using an in vitro model, we demonstrate that when CD4 T cells from HIV infected subjects are enriched from total blood lymphocytes the immune response to antigen is augmented. However, augmentation of this response is confined to HIV infected subjects with relatively preserved CD4 T cell counts. Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects.

KW - CD4

KW - HIV

KW - Lymphocyte

KW - Memory

KW - Mumps

KW - Proliferation

KW - Tetanus

UR - http://www.scopus.com/inward/record.url?scp=33845450189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845450189&partnerID=8YFLogxK

U2 - 10.1016/j.cellimm.2006.09.003

DO - 10.1016/j.cellimm.2006.09.003

M3 - Article

C2 - 17070790

AN - SCOPUS:33845450189

SN - 0008-8749

VL - 242

SP - 46

EP - 51

JO - Cellular Immunology

JF - Cellular Immunology

IS - 1

ER -

Functional impairment of CD4 T cells despite normalization of T cell number in HIV

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this