Functional chromatographic technique for natural product isolation

Eric C. Lau; Damian J. Mason; Nicole Eichhorst; Pearce Engelder; Celestina Mesa; E. M. Kithsiri Wijeratne; G. M.Kamal B. Gunaherath; A. A.Leslie Gunatilaka; James J. La Clair; Eli Chapman

doi:10.1039/c4ob02292k

Functional chromatographic technique for natural product isolation

Eric C. Lau, Damian J. Mason, Nicole Eichhorst, Pearce Engelder, Celestina Mesa, E. M. Kithsiri Wijeratne, G. M.Kamal B. Gunaherath, A. A.Leslie Gunatilaka, James J. La Clair, Eli Chapman

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.

Original language	English (US)
Pages (from-to)	2255-2259
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	8
DOIs	https://doi.org/10.1039/c4ob02292k
State	Published - 2015

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Functional chromatographic technique for natural product isolation",

abstract = "Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.",

author = "Lau, \{Eric C.\} and Mason, \{Damian J.\} and Nicole Eichhorst and Pearce Engelder and Celestina Mesa and \{Kithsiri Wijeratne\}, \{E. M.\} and Gunaherath, \{G. M.Kamal B.\} and Gunatilaka, \{A. A.Leslie\} and \{La Clair\}, \{James J.\} and Eli Chapman",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

doi = "10.1039/c4ob02292k",

language = "English (US)",

volume = "13",

pages = "2255--2259",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Functional chromatographic technique for natural product isolation

AU - Lau, Eric C.

AU - Mason, Damian J.

AU - Eichhorst, Nicole

AU - Engelder, Pearce

AU - Mesa, Celestina

AU - Kithsiri Wijeratne, E. M.

AU - Gunaherath, G. M.Kamal B.

AU - Gunatilaka, A. A.Leslie

AU - La Clair, James J.

AU - Chapman, Eli

PY - 2015

Y1 - 2015

N2 - Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.

AB - Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.

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UR - https://www.scopus.com/inward/citedby.url?scp=84922784531&partnerID=8YFLogxK

U2 - 10.1039/c4ob02292k

DO - 10.1039/c4ob02292k

M3 - Article

C2 - 25588099

AN - SCOPUS:84922784531

SN - 1477-0520

VL - 13

SP - 2255

EP - 2259

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 8

ER -

Functional chromatographic technique for natural product isolation

Abstract

ASJC Scopus subject areas

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