Functional chromatographic technique for natural product isolation

Eric C. Lau; Damian J. Mason; Nicole Eichhorst; Pearce Engelder; Celestina Mesa; E. M. Kithsiri Wijeratne; G. M.Kamal B. Gunaherath; A. A.Leslie Gunatilaka; James J. La Clair; Eli Chapman

doi:10.1039/c4ob02292k

Functional chromatographic technique for natural product isolation

Eric C. Lau
, Damian J. Mason
, Nicole Eichhorst
, Pearce Engelder
, Celestina Mesa
, E. M. Kithsiri Wijeratne
, G. M.Kamal B. Gunaherath
, A. A.Leslie Gunatilaka
, James J. La Clair
, Eli Chapman

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.

Original language	English (US)
Pages (from-to)	2255-2259
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	8
DOIs	https://doi.org/10.1039/c4ob02292k
State	Published - 2015

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Functional chromatographic technique for natural product isolation",

abstract = "Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.",

author = "Lau, \{Eric C.\} and Mason, \{Damian J.\} and Nicole Eichhorst and Pearce Engelder and Celestina Mesa and \{Kithsiri Wijeratne\}, \{E. M.\} and Gunaherath, \{G. M.Kamal B.\} and Gunatilaka, \{A. A.Leslie\} and \{La Clair\}, \{James J.\} and Eli Chapman",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

doi = "10.1039/c4ob02292k",

language = "English (US)",

volume = "13",

pages = "2255--2259",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Functional chromatographic technique for natural product isolation

AU - Lau, Eric C.

AU - Mason, Damian J.

AU - Eichhorst, Nicole

AU - Engelder, Pearce

AU - Mesa, Celestina

AU - Kithsiri Wijeratne, E. M.

AU - Gunaherath, G. M.Kamal B.

AU - Gunatilaka, A. A.Leslie

AU - La Clair, James J.

AU - Chapman, Eli

PY - 2015

Y1 - 2015

N2 - Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.

AB - Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.

UR - https://www.scopus.com/pages/publications/84922784531

UR - https://www.scopus.com/pages/publications/84922784531#tab=citedBy

U2 - 10.1039/c4ob02292k

DO - 10.1039/c4ob02292k

M3 - Article

C2 - 25588099

AN - SCOPUS:84922784531

SN - 1477-0520

VL - 13

SP - 2255

EP - 2259

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 8

ER -

Functional chromatographic technique for natural product isolation

Abstract

ASJC Scopus subject areas

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