Functional-Anatomic Fractionation of the Brain's Default Network

Jessica R. Andrews-Hanna, Jay S. Reidler, Jorge Sepulcre, Renee Poulin, Randy L. Buckner

Research output: Contribution to journalArticlepeer-review

1645 Scopus citations


One of the most consistent observations in human functional imaging is that a network of brain regions referred to as the "default network" increases its activity during passive states. Here we explored the anatomy and function of the default network across three studies to resolve divergent hypotheses about its contributions to spontaneous cognition and active forms of decision making. Analysis of intrinsic activity revealed the network comprises multiple, dissociated components. A midline core (posterior cingulate and anterior medial prefrontal cortex) is active when people make self-relevant, affective decisions. In contrast, a medial temporal lobe subsystem becomes engaged when decisions involve constructing a mental scene based on memory. During certain experimentally directed and spontaneous acts of future-oriented thought, these dissociated components are simultaneously engaged, presumably to facilitate construction of mental models of personally significant events.

Original languageEnglish (US)
Pages (from-to)550-562
Number of pages13
Issue number4
StatePublished - Feb 25 2010
Externally publishedYes



ASJC Scopus subject areas

  • Neuroscience(all)


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