Full optical model of micro-endoscope with optical coherence microscopy, multiphoton microscopy and visible capabilities

David Vega, Kelli C. Kiekens, Nikolas C. Syson, Gabriella Romano, Tressa Baker, Jennifer K. Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations


While Optical Coherence Microscopy (OCM), Multiphoton Microscopy (MPM), and narrowband imaging are powerful imaging techniques that can be used to detect cancer, each imaging technique has limitations when used by itself. Combining them into an endoscope to work in synergy can help achieve high sensitivity and specificity for diagnosis at the point of care. Such complex endoscopes have an elevated risk of failure, and performing proper modelling ensures functionality and minimizes risk. We present full 2D and 3D models of a multimodality optical micro-endoscope to provide real-time detection of carcinomas, called a salpingoscope. The models evaluate the endoscope illumination and light collection capabilities of various modalities. The design features two optical paths with different numerical apertures (NA) through a single lens system with a scanning optical fiber. The dual path is achieved using dichroic coatings embedded in a triplet. A high NA optical path is designed to perform OCM and MPM while a low NA optical path is designed for the visible spectrum to navigate the endoscope to areas of interest and narrowband imaging. Different tests such as the reflectance profile of homogeneous epithelial tissue were performed to adjust the models properly. Light collection models for the different modalities were created and tested for efficiency. While it is challenging to evaluate the efficiency of multimodality endoscopes, the models ensure that the system is design for the expected light collection levels to provide detectable signal to work for the intended imaging.

Original languageEnglish (US)
Title of host publicationEndoscopic Microscopy XIII
EditorsMelissa J. Suter, Guillermo J. Tearney, Thomas D. Wang
ISBN (Electronic)9781510614253
StatePublished - 2018
EventEndoscopic Microscopy XIII 2018 - San Francisco, United States
Duration: Jan 27 2018Jan 29 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherEndoscopic Microscopy XIII 2018
Country/TerritoryUnited States
CitySan Francisco


  • MPM
  • OCM
  • OCT
  • micro-endoscope
  • multimodal endoscopy
  • optical design

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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