@inproceedings{132a243546de44d08fe30b8899f67394,
title = "Full optical model of micro-endoscope with optical coherence microscopy, multiphoton microscopy and visible capabilities",
abstract = "While Optical Coherence Microscopy (OCM), Multiphoton Microscopy (MPM), and narrowband imaging are powerful imaging techniques that can be used to detect cancer, each imaging technique has limitations when used by itself. Combining them into an endoscope to work in synergy can help achieve high sensitivity and specificity for diagnosis at the point of care. Such complex endoscopes have an elevated risk of failure, and performing proper modelling ensures functionality and minimizes risk. We present full 2D and 3D models of a multimodality optical micro-endoscope to provide real-time detection of carcinomas, called a salpingoscope. The models evaluate the endoscope illumination and light collection capabilities of various modalities. The design features two optical paths with different numerical apertures (NA) through a single lens system with a scanning optical fiber. The dual path is achieved using dichroic coatings embedded in a triplet. A high NA optical path is designed to perform OCM and MPM while a low NA optical path is designed for the visible spectrum to navigate the endoscope to areas of interest and narrowband imaging. Different tests such as the reflectance profile of homogeneous epithelial tissue were performed to adjust the models properly. Light collection models for the different modalities were created and tested for efficiency. While it is challenging to evaluate the efficiency of multimodality endoscopes, the models ensure that the system is design for the expected light collection levels to provide detectable signal to work for the intended imaging.",
keywords = "MPM, OCM, OCT, micro-endoscope, multimodal endoscopy, optical design",
author = "David Vega and Kiekens, {Kelli C.} and Syson, {Nikolas C.} and Gabriella Romano and Tressa Baker and Barton, {Jennifer K.}",
note = "Funding Information: Research supported in part by the National Institutes of Health (NIH/NIBIB 1R01EB020605) and NSF Graduate Research Fellowship Program (NSF-GRFP). Funding Information: Research supported in part by the National Institutes of Health Research Fellowship Program (NSF-GRFP). Publisher Copyright: {\textcopyright} 2018 SPIE.; Endoscopic Microscopy XIII 2018 ; Conference date: 27-01-2018 Through 29-01-2018",
year = "2018",
doi = "10.1117/12.2285059",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Suter, {Melissa J.} and Tearney, {Guillermo J.} and Wang, {Thomas D.}",
booktitle = "Endoscopic Microscopy XIII",
}