Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype

Carl Friddle; Rebecca Koskela; Koustubh Ranade; Joan Hebert; Michele Cargill; Chris D. Clark; Melvin McInnis; Sylvia Simpson; Francis McMahon; O. Colin Stine; Deborah Meyers; Jianfeng Xu; Dean MacKinnon; Theresa Swift-Scanlan; Kay Jamison; Susan Folstein; Mark Daly; Leonid Kruglyak; Thomas Marr; J. Raymond DePaulo; David Botstein

doi:10.1086/302697

Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype

Carl Friddle
, Rebecca Koskela
, Koustubh Ranade
, Joan Hebert
, Michele Cargill
, Chris D. Clark
, Melvin McInnis
, Sylvia Simpson
, Francis McMahon
, O. Colin Stine
, Deborah Meyers
, Jianfeng Xu
, Dean MacKinnon
, Theresa Swift-Scanlan
, Kay Jamison
, Susan Folstein
, Mark Daly
, Leonid Kruglyak
, Thomas Marr
, J. Raymond DePaulo

David Botstein

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

A genome scan of ~12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.

Original language	English (US)
Pages (from-to)	205-215
Number of pages	11
Journal	American Journal of Human Genetics
Volume	66
Issue number	1
DOIs	https://doi.org/10.1086/302697
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Access to Document

10.1086/302697

Cite this

Friddle, C., Koskela, R., Ranade, K., Hebert, J., Cargill, M., Clark, C. D., McInnis, M., Simpson, S., McMahon, F., Stine, O. C., Meyers, D., Xu, J., MacKinnon, D., Swift-Scanlan, T., Jamison, K., Folstein, S., Daly, M., Kruglyak, L., Marr, T., ... Botstein, D. (2000). Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. American Journal of Human Genetics, 66(1), 205-215. https://doi.org/10.1086/302697

Friddle, C, Koskela, R, Ranade, K, Hebert, J, Cargill, M, Clark, CD, McInnis, M, Simpson, S, McMahon, F, Stine, OC, Meyers, D, Xu, J, MacKinnon, D, Swift-Scanlan, T, Jamison, K, Folstein, S, Daly, M, Kruglyak, L, Marr, T, DePaulo, JR & Botstein, D 2000, 'Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype', American Journal of Human Genetics, vol. 66, no. 1, pp. 205-215. https://doi.org/10.1086/302697

@article{4249ab4f1cd9438088c89ad0fff84443,

title = "Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype",

abstract = "A genome scan of \textasciitilde{}12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.",

author = "Carl Friddle and Rebecca Koskela and Koustubh Ranade and Joan Hebert and Michele Cargill and Clark, \{Chris D.\} and Melvin McInnis and Sylvia Simpson and Francis McMahon and Stine, \{O. Colin\} and Deborah Meyers and Jianfeng Xu and Dean MacKinnon and Theresa Swift-Scanlan and Kay Jamison and Susan Folstein and Mark Daly and Leonid Kruglyak and Thomas Marr and DePaulo, \{J. Raymond\} and David Botstein",

note = "Funding Information: This work was supported by grants from the Charles A. Dana Foundation Consortium on the Genetic Basis of Manic Depressive Illness, the National Institutes of Mental Health, the National Alliance for Research on Schizophrenia and Depression, and the Theodore and Vada Stanley Foundation and by contributors to the Affective Disorders Fund and the George Browne Laboratory Fund at Johns Hopkins University. We thank Paul McHugh and James Watson for their contributions to the planning of this study and for helpful criticism. We thank the residents and faculty of the Johns Hopkins University Department of Psychiatry, who referred families for this study. Finally, we thank the many families without whose collaboration this study would not have been possible. ",

year = "2000",

doi = "10.1086/302697",

language = "English (US)",

volume = "66",

pages = "205--215",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype

AU - Friddle, Carl

AU - Koskela, Rebecca

AU - Ranade, Koustubh

AU - Hebert, Joan

AU - Cargill, Michele

AU - Clark, Chris D.

AU - McInnis, Melvin

AU - Simpson, Sylvia

AU - McMahon, Francis

AU - Stine, O. Colin

AU - Meyers, Deborah

AU - Xu, Jianfeng

AU - MacKinnon, Dean

AU - Swift-Scanlan, Theresa

AU - Jamison, Kay

AU - Folstein, Susan

AU - Daly, Mark

AU - Kruglyak, Leonid

AU - Marr, Thomas

AU - DePaulo, J. Raymond

AU - Botstein, David

N1 - Funding Information: This work was supported by grants from the Charles A. Dana Foundation Consortium on the Genetic Basis of Manic Depressive Illness, the National Institutes of Mental Health, the National Alliance for Research on Schizophrenia and Depression, and the Theodore and Vada Stanley Foundation and by contributors to the Affective Disorders Fund and the George Browne Laboratory Fund at Johns Hopkins University. We thank Paul McHugh and James Watson for their contributions to the planning of this study and for helpful criticism. We thank the residents and faculty of the Johns Hopkins University Department of Psychiatry, who referred families for this study. Finally, we thank the many families without whose collaboration this study would not have been possible.

PY - 2000

Y1 - 2000

N2 - A genome scan of ~12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.

AB - A genome scan of ~12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.

UR - https://www.scopus.com/pages/publications/0033909667

UR - https://www.scopus.com/pages/publications/0033909667#tab=citedBy

U2 - 10.1086/302697

DO - 10.1086/302697

M3 - Article

C2 - 10631152

AN - SCOPUS:0033909667

SN - 0002-9297

VL - 66

SP - 205

EP - 215

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 1

ER -

Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this