From initiation to elongation: comparison of transcription by prokaryotic and eukaryotic RNA polymerases

Dirk Eick; Andrew Wedel; Hermann Heumann

doi:10.1016/0168-9525(90)90013-V

From initiation to elongation: comparison of transcription by prokaryotic and eukaryotic RNA polymerases

Dirk Eick, Andrew Wedel, Hermann Heumann

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Multisubunit RNA polymerases in prokaryotes and eukaryotes share an evolutionarily conserved core. Here, we compare the processes of promoter recognition, transcription initiation and transcript elongation by human RNA polymerase II and by the RNA polymerase of the eubacterium Escherichia coli. Although these two polymerases have diverged widely in structure, important functions have been conserved, suggesting that the basic mechanisms of RNA transcription are similar in eukaryotes and prokaryotes.

Original language	English (US)
Pages (from-to)	292-296
Number of pages	5
Journal	Trends in Genetics
Volume	10
Issue number	8
DOIs	https://doi.org/10.1016/0168-9525(90)90013-V
State	Published - Aug 1994
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1016/0168-9525(90)90013-V

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title = "From initiation to elongation: comparison of transcription by prokaryotic and eukaryotic RNA polymerases",

abstract = "Multisubunit RNA polymerases in prokaryotes and eukaryotes share an evolutionarily conserved core. Here, we compare the processes of promoter recognition, transcription initiation and transcript elongation by human RNA polymerase II and by the RNA polymerase of the eubacterium Escherichia coli. Although these two polymerases have diverged widely in structure, important functions have been conserved, suggesting that the basic mechanisms of RNA transcription are similar in eukaryotes and prokaryotes.",

author = "Dirk Eick and Andrew Wedel and Hermann Heumann",

note = "Funding Information: Becauseo f spacer estrictionns,o ta lls tudiest hatc ontributed to the ideasd escribedh erec ould be cited directly,W e thank memberso f our laboratoriefso r criticalc ommentsa nd discussion. Our researchw as supportedb y grants from the DeutscheF orschungsgeraelnschaanftd Fonds der Chemlschen lndustrleA, ,W. holds a Humboldtp ostdoctorafle llowship,",

year = "1994",

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doi = "10.1016/0168-9525(90)90013-V",

language = "English (US)",

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journal = "Trends in Genetics",

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T1 - From initiation to elongation

T2 - comparison of transcription by prokaryotic and eukaryotic RNA polymerases

AU - Eick, Dirk

AU - Wedel, Andrew

AU - Heumann, Hermann

N1 - Funding Information: Becauseo f spacer estrictionns,o ta lls tudiest hatc ontributed to the ideasd escribedh erec ould be cited directly,W e thank memberso f our laboratoriefso r criticalc ommentsa nd discussion. Our researchw as supportedb y grants from the DeutscheF orschungsgeraelnschaanftd Fonds der Chemlschen lndustrleA, ,W. holds a Humboldtp ostdoctorafle llowship,

PY - 1994/8

Y1 - 1994/8

N2 - Multisubunit RNA polymerases in prokaryotes and eukaryotes share an evolutionarily conserved core. Here, we compare the processes of promoter recognition, transcription initiation and transcript elongation by human RNA polymerase II and by the RNA polymerase of the eubacterium Escherichia coli. Although these two polymerases have diverged widely in structure, important functions have been conserved, suggesting that the basic mechanisms of RNA transcription are similar in eukaryotes and prokaryotes.

AB - Multisubunit RNA polymerases in prokaryotes and eukaryotes share an evolutionarily conserved core. Here, we compare the processes of promoter recognition, transcription initiation and transcript elongation by human RNA polymerase II and by the RNA polymerase of the eubacterium Escherichia coli. Although these two polymerases have diverged widely in structure, important functions have been conserved, suggesting that the basic mechanisms of RNA transcription are similar in eukaryotes and prokaryotes.

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U2 - 10.1016/0168-9525(90)90013-V

DO - 10.1016/0168-9525(90)90013-V

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JF - Trends in Genetics

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From initiation to elongation: comparison of transcription by prokaryotic and eukaryotic RNA polymerases

Abstract

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