Frequency-specific network connectivity increases underlie accurate spatiotemporal memory retrieval

Andrew J. Watrous, Nitin Tandon, Chris R. Conner, Thomas Pieters, Arne D. Ekstrom

Research output: Contribution to journalArticlepeer-review

221 Scopus citations

Abstract

The medial temporal lobes, prefrontal cortex and parts of parietal cortex form the neural underpinnings of episodic memory, which includes remembering both where and when an event occurred. However, the manner in which these three regions interact during retrieval of spatial and temporal context remains untested. We employed simultaneous electrocorticographical recordings across multilobular regions in patients undergoing seizure monitoring while they retrieved spatial and temporal context associated with an episode, and we used phase synchronization as a measure of network connectivity. Successful memory retrieval was characterized by greater global connectivity compared with incorrect retrieval, with the medial temporal lobe acting as a hub for these interactions. Spatial versus temporal context retrieval resulted in prominent differences in both the spectral and temporal patterns of network interactions. These results emphasize dynamic network interactions as being central to episodic memory retrieval, providing insight into how multiple contexts underlying a single event can be recreated in the same network.

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalNature neuroscience
Volume16
Issue number3
DOIs
StatePublished - Mar 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience

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