Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria

Jesse Fajnzylber; Radwa Sharaf; John N. Hutchinson; Evgenia Aga; Ronald J. Bosch; Wendy Hartogensis; Jeffrey M. Jacobson; Elizabeth Connick; Paul Volberding; Daniel J. Skiest; David Margolis; Michael C. Sneller; Susan J. Little; Roy M. Gulick; John W. Mellors; Rajesh T. Gandhi; Robert T. Schooley; Keith Henry; Pablo Tebas; Steve Deeks; Tae Wook Chun; Ann C. Collier; Frederick M. Hecht; Jonathan Z. Li

doi:10.1097/QAD.0000000000002978

Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria

Jesse Fajnzylber
, Radwa Sharaf
, John N. Hutchinson
, Evgenia Aga
, Ronald J. Bosch
, Wendy Hartogensis
, Jeffrey M. Jacobson
, Elizabeth Connick
, Paul Volberding
, Daniel J. Skiest
, David Margolis
, Michael C. Sneller
, Susan J. Little
, Roy M. Gulick
, John W. Mellors
, Rajesh T. Gandhi
, Robert T. Schooley
, Keith Henry
, Pablo Tebas
, Steve Deeks

Tae Wook Chun, Ann C. Collier, Frederick M. Hecht, Jonathan Z. Li

Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000cps/ml provides both high specificity and sensitivity for PTC detection. PTC frequency varies greatly based on the definition of a PTC.

Original language	English (US)
Pages (from-to)	2225-2227
Number of pages	3
Journal	AIDS
Volume	35
Issue number	13
DOIs	https://doi.org/10.1097/QAD.0000000000002978
State	Published - Nov 1 2021

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/QAD.0000000000002978

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Fajnzylber, J., Sharaf, R., Hutchinson, J. N., Aga, E., Bosch, R. J., Hartogensis, W., Jacobson, J. M., Connick, E., Volberding, P., Skiest, D. J., Margolis, D., Sneller, M. C., Little, S. J., Gulick, R. M., Mellors, J. W., Gandhi, R. T., Schooley, R. T., Henry, K., Tebas, P., ... Li, J. Z. (2021). Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria. AIDS, 35(13), 2225-2227. https://doi.org/10.1097/QAD.0000000000002978

Fajnzylber, J, Sharaf, R, Hutchinson, JN, Aga, E, Bosch, RJ, Hartogensis, W, Jacobson, JM, Connick, E, Volberding, P, Skiest, DJ, Margolis, D, Sneller, MC, Little, SJ, Gulick, RM, Mellors, JW, Gandhi, RT, Schooley, RT, Henry, K, Tebas, P, Deeks, S, Chun, TW, Collier, AC, Hecht, FM & Li, JZ 2021, 'Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria', AIDS, vol. 35, no. 13, pp. 2225-2227. https://doi.org/10.1097/QAD.0000000000002978

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title = "Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria",

abstract = "Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000cps/ml provides both high specificity and sensitivity for PTC detection. PTC frequency varies greatly based on the definition of a PTC.",

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AU - Fajnzylber, Jesse

AU - Sharaf, Radwa

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AU - Bosch, Ronald J.

AU - Hartogensis, Wendy

AU - Jacobson, Jeffrey M.

AU - Connick, Elizabeth

AU - Volberding, Paul

AU - Skiest, Daniel J.

AU - Margolis, David

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AU - Little, Susan J.

AU - Gulick, Roy M.

AU - Mellors, John W.

AU - Gandhi, Rajesh T.

AU - Schooley, Robert T.

AU - Henry, Keith

AU - Tebas, Pablo

AU - Deeks, Steve

AU - Chun, Tae Wook

AU - Collier, Ann C.

AU - Hecht, Frederick M.

AU - Li, Jonathan Z.

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AB - Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000cps/ml provides both high specificity and sensitivity for PTC detection. PTC frequency varies greatly based on the definition of a PTC.

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ER -

Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria

Abstract

ASJC Scopus subject areas

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