@article{732909ed018d416e934e78957dc94059,
title = "Frequency of post treatment control varies by antiretroviral therapy restart and viral load criteria",
abstract = "Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000cps/ml provides both high specificity and sensitivity for PTC detection. PTC frequency varies greatly based on the definition of a PTC.",
author = "Jesse Fajnzylber and Radwa Sharaf and Hutchinson, {John N.} and Evgenia Aga and Bosch, {Ronald J.} and Wendy Hartogensis and Jacobson, {Jeffrey M.} and Elizabeth Connick and Paul Volberding and Skiest, {Daniel J.} and David Margolis and Sneller, {Michael C.} and Little, {Susan J.} and Gulick, {Roy M.} and Mellors, {John W.} and Gandhi, {Rajesh T.} and Schooley, {Robert T.} and Keith Henry and Pablo Tebas and Steve Deeks and Chun, {Tae Wook} and Collier, {Ann C.} and Hecht, {Frederick M.} and Li, {Jonathan Z.}",
note = "Funding Information: This work was supported in part by the Harvard University Center for AIDS Research (to Drs Li and Gandhi, NIAID 5P30AI060354–08); National Institutes of Health (NIH) grants UM1 AI068634 (Statistical and Data Management Center of the AIDS Clinical Trials Group), UM1 AI068636 (AIDS Clinical Trials Group), subcontract from UM1 AI106701 to the Harvard Virology Support Laboratory (to Dr Li); The Foundation for AIDS Research (amfAR to Dr Li); Harvard University Center for AIDS Research (CFAR, to Dr Hutchinson); and an NIH funded program P30 AI060354 (to Dr Hutchinson), which is supported by the following NIH Co-Funding and Participating Institutes and Centers: NIAID, NCI, NICHD, NHLBI, NIDA, NIMH, NIA, NIDDK, NIGMS, FIC, and OAR. Publisher Copyright: {\textcopyright} 2021 Lippincott Williams and Wilkins. All rights reserved.",
year = "2021",
month = nov,
day = "1",
doi = "10.1097/QAD.0000000000002978",
language = "English (US)",
volume = "35",
pages = "2225--2227",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "13",
}