Freeze-drying above room temperature

Marc S. Tesconi; Kiaresh Sepassi; Samuel H. Yalkowsky

doi:10.1021/js980478p

Freeze-drying above room temperature

Marc S. Tesconi
, Kiaresh Sepassi
, Samuel H. Yalkowsky

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

This study investigates the use of solid, organic compounds to lyophilize drugs without conventional freeze-drying equipment. The aim of the investigation is to find a pharmaceutically acceptable solvent or solvent combination that is appropriate for freeze-drying on the basis of its ability to (1) solubilize hydrophobic drugs, (2) provide a stable environment for water-sensitive compounds, (3) be rapidly and completely removed from the product under vacuum, and (4) produce cakes that are readily reconstituted. A eutectic formed from 1,1,1-trichloro-2-methyl-2-propanol (chlorobutanol) hemihydrate and dimethyl sulfone (DMSO₂) is determined to be a suitable medium.

Original language	English (US)
Pages (from-to)	501-506
Number of pages	6
Journal	Journal of pharmaceutical sciences
Volume	88
Issue number	5
DOIs	https://doi.org/10.1021/js980478p
State	Published - May 1999

ASJC Scopus subject areas

Pharmaceutical Science

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10.1021/js980478p

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AU - Yalkowsky, Samuel H.

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AB - This study investigates the use of solid, organic compounds to lyophilize drugs without conventional freeze-drying equipment. The aim of the investigation is to find a pharmaceutically acceptable solvent or solvent combination that is appropriate for freeze-drying on the basis of its ability to (1) solubilize hydrophobic drugs, (2) provide a stable environment for water-sensitive compounds, (3) be rapidly and completely removed from the product under vacuum, and (4) produce cakes that are readily reconstituted. A eutectic formed from 1,1,1-trichloro-2-methyl-2-propanol (chlorobutanol) hemihydrate and dimethyl sulfone (DMSO2) is determined to be a suitable medium.

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Freeze-drying above room temperature

Abstract

ASJC Scopus subject areas

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