Freeze-drying above room temperature

Marc S. Tesconi, Kiaresh Sepassi, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


This study investigates the use of solid, organic compounds to lyophilize drugs without conventional freeze-drying equipment. The aim of the investigation is to find a pharmaceutically acceptable solvent or solvent combination that is appropriate for freeze-drying on the basis of its ability to (1) solubilize hydrophobic drugs, (2) provide a stable environment for water-sensitive compounds, (3) be rapidly and completely removed from the product under vacuum, and (4) produce cakes that are readily reconstituted. A eutectic formed from 1,1,1-trichloro-2-methyl-2-propanol (chlorobutanol) hemihydrate and dimethyl sulfone (DMSO2) is determined to be a suitable medium.

Original languageEnglish (US)
Pages (from-to)501-506
Number of pages6
JournalJournal of pharmaceutical sciences
Issue number5
StatePublished - May 1999

ASJC Scopus subject areas

  • Pharmaceutical Science


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