TY - JOUR
T1 - Freeze-drying above room temperature
AU - Tesconi, Marc S.
AU - Sepassi, Kiaresh
AU - Yalkowsky, Samuel H.
PY - 1999/5
Y1 - 1999/5
N2 - This study investigates the use of solid, organic compounds to lyophilize drugs without conventional freeze-drying equipment. The aim of the investigation is to find a pharmaceutically acceptable solvent or solvent combination that is appropriate for freeze-drying on the basis of its ability to (1) solubilize hydrophobic drugs, (2) provide a stable environment for water-sensitive compounds, (3) be rapidly and completely removed from the product under vacuum, and (4) produce cakes that are readily reconstituted. A eutectic formed from 1,1,1-trichloro-2-methyl-2-propanol (chlorobutanol) hemihydrate and dimethyl sulfone (DMSO2) is determined to be a suitable medium.
AB - This study investigates the use of solid, organic compounds to lyophilize drugs without conventional freeze-drying equipment. The aim of the investigation is to find a pharmaceutically acceptable solvent or solvent combination that is appropriate for freeze-drying on the basis of its ability to (1) solubilize hydrophobic drugs, (2) provide a stable environment for water-sensitive compounds, (3) be rapidly and completely removed from the product under vacuum, and (4) produce cakes that are readily reconstituted. A eutectic formed from 1,1,1-trichloro-2-methyl-2-propanol (chlorobutanol) hemihydrate and dimethyl sulfone (DMSO2) is determined to be a suitable medium.
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U2 - 10.1021/js980478p
DO - 10.1021/js980478p
M3 - Article
C2 - 10229639
AN - SCOPUS:0032950326
SN - 0022-3549
VL - 88
SP - 501
EP - 506
JO - Journal of pharmaceutical sciences
JF - Journal of pharmaceutical sciences
IS - 5
ER -