Frailty in Parkinson's disease and its clinical implications

Nasiya N. Ahmed; Scott J. Sherman; David VanWyck

doi:10.1016/j.parkreldis.2007.10.004

Frailty in Parkinson's disease and its clinical implications

Nasiya N. Ahmed, Scott J. Sherman, David VanWyck

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

The purpose of our study was to determine the prevalence of frailty in Parkinson's disease (PD) patients and the relationship between individual frailty criteria and the severity of PD. We measured the five components of frailty (Fried et al.) and the severity of PD (unified Parkinson's disease rating scale (UPDRS)) in 50 optimally treated PD patients. Frailty was more prevalent in PD patients. While UPDRS scores differed between frail and non-frail participants (44.8±15.8 vs. 31.4±12.7, P<0.002), higher scores were not indicative of frailty. Weekly caloric expenditure best predicted frailty status (OR=22.0 [4.5,107.8]). Frailty and PD bear distinct therapeutic and prognostic significance; however, their clinical picture may overlap and screening PD patients for frailty may be warranted.

Original language	English (US)
Pages (from-to)	334-337
Number of pages	4
Journal	Parkinsonism and Related Disorders
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.parkreldis.2007.10.004
State	Published - May 2008

Keywords

Frailty
Geriatrics
Parkinson's disease

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2007.10.004

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Frailty in Parkinson's disease and its clinical implications

Abstract

Keywords

ASJC Scopus subject areas

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