Four years' experience with fibrin sealant in thoracic and cardiovascular surgery

Thomas L. Matthew, William D. Spotnitz, Irving L. Kron, Thomas M. Daniel, Curtis G. Tribble, Stanton P. Nolan

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


A single-donor fibrin sealant system was used in 689 thoracic and cardiovascular surgical procedures over the 4-year period between April 1, 1985, and March 31, 1989. An excellent overall success rate ( 646 689, 94% effective) was achieved with specific applications, including reduction of leakage of air ( 29 33, 88% effective), blood ( 595 634, 94% effective), and fluid ( 14 14, 100% effective), as well as positioning of anatomical structures such as coronary bypass grafts ( 8 8, 100% effective). Application methods included use of spray bottles ( 477 497, 96% effective), syringes ( 165 186, 89% effective), and a Silastic cannula through the flexible fiber-optic bronchoscope ( 4 6, 67% effective). The system was used in a wide variety of cardiac, pulmonary, esophageal, and vascular procedures to seal staple lines, suture lines, anastomoses, conduits, fistulas, and raw surfaces. No complications with this single-donor system secondary to blood-borne disease have been documented. Overall infection occurred at a nominal rate ( 16 689, 2%). Thus, fibrin sealant has been a useful tool to control the leakage of air, blood, and fluid during a wide variety of thoracic and cardiovascular procedures and may be of benefit to other surgeons.

Original languageEnglish (US)
Pages (from-to)40-43
Number of pages4
JournalThe Annals of Thoracic Surgery
Issue number1
StatePublished - Jul 1990

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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