Formulation and in vivo evaluation of ocular insert containing phenylephrine and tropicamide

Yung Chi Lee, Jeffrey W. Millard, Gerald J. Negvesky, Salim I. Butrus, Samuel H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A Gelfoam® based ocular device containing 1.7 mg of phenylephrine and 0.6 mg of tropicamide was formulated and evaluated for pupillary dilation in rabbits. The manufacturing procedure is fairly simple and the required excipients are inexpensive. The in vivo results show that the mydriatic response produced by the proposed device is larger and longer lasting than that produced by eyedrops with an equivalent amount of phenylephrine and tropicamide. The results reported in this study, along with those of previous studies, imply that Gelfoam® is a versatile drug carrier for either local or systemic drug delivery via the ophthalmic route. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalInternational Journal of Pharmaceutics
Issue number1
StatePublished - May 10 1999


  • Gelfoam®
  • Mydriasis
  • Mydriatic
  • Ocular device
  • Phenylephrine
  • Tropicamide

ASJC Scopus subject areas

  • Pharmaceutical Science


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