Formation of self-assembled, air-stable lipid bilayer membranes on solid supports

Eric E. Ross, Bruce Bondurant, Tony Spratt, John C. Conboy, David F. O'Brien, S. Scott Saavedra

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


A successful strategy for the self-assembly and stabilization of a substrate-supported, phospholipid bilayer is described. The bilayer is self-organized by fusion of fluid vesicles, composed of bissorbylphosphatidylcholine, on an oxide surface. The supported bilayer is then polymerized in situ to produce a cross-linked structure that is stable to surfactant solutions, organic solvents, and to transfer across the air/water interface, yet retains the resistance to nonspecific protein adsorption characteristic of a fluid phosphatidylcholine bilayer.

Original languageEnglish (US)
Pages (from-to)2305-2307
Number of pages3
Issue number8
StatePublished - Apr 17 2001

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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