Formation of dihydronaphthalenes via organocatalytic enatioselective michael-aldol cascade reactions with arylalkanes

Xiangmin Li, Sinan Wang, Tengfei Li, Jian Li, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

An organocatalytic highly enantioselective Michael-aldol cascade access to valuable chiral dihydronaphthalenes has been realized. Notably, the strategy via activation of nucleophilic alkyl chains by introducing nitro, chloro, or CF3 group(s) at the ortho- and/or para-position(s) on an aromatic ring renders them readily deprotonated to produce highly reactive nulecophilic species in the cascade process under mild conditions.

Original languageEnglish (US)
Pages (from-to)5634-5637
Number of pages4
JournalOrganic Letters
Volume15
Issue number22
DOIs
StatePublished - Nov 15 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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