Footshock produces analgesia but no gastrointestinal motility effects in the rat

James J. Galligan; Frank Porreca; Thomas F. Burks

doi:10.1016/0024-3205(83)90544-1

Footshock produces analgesia but no gastrointestinal motility effects in the rat

James J. Galligan, Frank Porreca, Thomas F. Burks

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The effect of inescapable footshock was determined on gastrointestinal motility in unanesthetized rats. Inescapable footshock did not affect gastric emptying, small or large intestinal transit. Footshock produced a brief, naloxone-reversible thermal analgesia. These data indicate that gastrointestinal motility and analgesia are controlled by different central nervous system opioid mechanisms.

Original language	English (US)
Pages (from-to)	473-475
Number of pages	3
Journal	Life Sciences
Volume	33
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/0024-3205(83)90544-1
State	Published - 1983

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(83)90544-1

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title = "Footshock produces analgesia but no gastrointestinal motility effects in the rat",

abstract = "The effect of inescapable footshock was determined on gastrointestinal motility in unanesthetized rats. Inescapable footshock did not affect gastric emptying, small or large intestinal transit. Footshock produced a brief, naloxone-reversible thermal analgesia. These data indicate that gastrointestinal motility and analgesia are controlled by different central nervous system opioid mechanisms.",

author = "Galligan, {James J.} and Frank Porreca and Burks, {Thomas F.}",

note = "Funding Information: Supported by DA02163, a PMAF predoctoral fellowship (JJG) and a Merck postdoctoral fellowship (FP). Naloxone was a gift from Endo Laboratories, Garden City, New York.",

year = "1983",

doi = "10.1016/0024-3205(83)90544-1",

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T1 - Footshock produces analgesia but no gastrointestinal motility effects in the rat

AU - Galligan, James J.

AU - Porreca, Frank

AU - Burks, Thomas F.

N1 - Funding Information: Supported by DA02163, a PMAF predoctoral fellowship (JJG) and a Merck postdoctoral fellowship (FP). Naloxone was a gift from Endo Laboratories, Garden City, New York.

PY - 1983

Y1 - 1983

N2 - The effect of inescapable footshock was determined on gastrointestinal motility in unanesthetized rats. Inescapable footshock did not affect gastric emptying, small or large intestinal transit. Footshock produced a brief, naloxone-reversible thermal analgesia. These data indicate that gastrointestinal motility and analgesia are controlled by different central nervous system opioid mechanisms.

AB - The effect of inescapable footshock was determined on gastrointestinal motility in unanesthetized rats. Inescapable footshock did not affect gastric emptying, small or large intestinal transit. Footshock produced a brief, naloxone-reversible thermal analgesia. These data indicate that gastrointestinal motility and analgesia are controlled by different central nervous system opioid mechanisms.

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U2 - 10.1016/0024-3205(83)90544-1

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EP - 475

JO - Life Sciences

JF - Life Sciences

IS - SUPPL. 1

ER -

Footshock produces analgesia but no gastrointestinal motility effects in the rat

Abstract

ASJC Scopus subject areas

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