Foot-shock induced stress increases β-endorphin levels in blood but not brain

Jean Rossier; Edward D. French; Catherine Rivier; Nicholas Ling; Roger Guillemin; Floyd E. Bloom

doi:10.1038/270618a0

Foot-shock induced stress increases β-endorphin levels in blood but not brain

Jean Rossier, Edward D. French, Catherine Rivier, Nicholas Ling, Roger Guillemin, Floyd E. Bloom

Research output: Contribution to journal › Article › peer-review

439 Scopus citations

Abstract

FOOT-SHOCK induced stress promotes a five to sixfold increase in β-endorphin plasma levels. Similar increases were also found for ACTH plasma levels. In the hypothalamus, foot-shock induced stress promotes a decrease of β-endorphin assayed by radioimmunoassays. These data suggest that physiological increases in plasma β-endorphin levels induced by stress do not result in elevated levels of brain β-endorphin.

Original language	English (US)
Pages (from-to)	618-620
Number of pages	3
Journal	Nature
Volume	270
Issue number	5638
DOIs	https://doi.org/10.1038/270618a0
State	Published - 1977
Externally published	Yes

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title = "Foot-shock induced stress increases β-endorphin levels in blood but not brain",

abstract = "FOOT-SHOCK induced stress promotes a five to sixfold increase in β-endorphin plasma levels. Similar increases were also found for ACTH plasma levels. In the hypothalamus, foot-shock induced stress promotes a decrease of β-endorphin assayed by radioimmunoassays. These data suggest that physiological increases in plasma β-endorphin levels induced by stress do not result in elevated levels of brain β-endorphin.",

author = "Jean Rossier and French, {Edward D.} and Catherine Rivier and Nicholas Ling and Roger Guillemin and Bloom, {Floyd E.}",

year = "1977",

doi = "10.1038/270618a0",

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T1 - Foot-shock induced stress increases β-endorphin levels in blood but not brain

AU - Rossier, Jean

AU - French, Edward D.

AU - Rivier, Catherine

AU - Ling, Nicholas

AU - Guillemin, Roger

AU - Bloom, Floyd E.

PY - 1977

Y1 - 1977

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Foot-shock induced stress increases β-endorphin levels in blood but not brain

Abstract

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