TY - JOUR
T1 - Follicle regulatory protein
T2 - A novel marker for granulosa cell cancer patients
AU - Rodgers, Kathleen E.
AU - Marks, Jamie F.
AU - Ellefson, Dolph D.
AU - Yanagihara, Donna L.
AU - Tonetta, Sharon A.
AU - Vasilev, Steven A.
AU - Morrow, C. Paul
AU - Montz, Fredrick J.
AU - diZerega, Gere S.
PY - 1990/6
Y1 - 1990/6
N2 - Follicle regulatory protein (FRP) is secreted by the granulosa cell of the ovary and plays a role in modulating follicle development. A dual epitope immunoassay using two murine monoclonal antibodies, isotype IgG1 (raised against porcine FRP), in tandem was developed to measure FRP in serum. The levels of FRP in the serum of women with granulosa cell tumors, normal, menstruating women, and postmenopausal women were determined. The levels of FRP were elevated in the serum of 79% of the women with granulosa cell tumors compared to the normal controls. FRP levels in serial samples from women with granulosa cell tumors generally correlated with the clinical course of the disease. Thus, FRP may provide a useful marker for granulosa cell tumors.
AB - Follicle regulatory protein (FRP) is secreted by the granulosa cell of the ovary and plays a role in modulating follicle development. A dual epitope immunoassay using two murine monoclonal antibodies, isotype IgG1 (raised against porcine FRP), in tandem was developed to measure FRP in serum. The levels of FRP in the serum of women with granulosa cell tumors, normal, menstruating women, and postmenopausal women were determined. The levels of FRP were elevated in the serum of 79% of the women with granulosa cell tumors compared to the normal controls. FRP levels in serial samples from women with granulosa cell tumors generally correlated with the clinical course of the disease. Thus, FRP may provide a useful marker for granulosa cell tumors.
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U2 - 10.1016/0090-8258(90)90372-R
DO - 10.1016/0090-8258(90)90372-R
M3 - Article
C2 - 1693585
AN - SCOPUS:0025311915
SN - 0090-8258
VL - 37
SP - 381
EP - 387
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 3
ER -