fMRI of visual system activation in the conscious rabbit

Alice M. Wyrwicz; Nan Kuei Chen; Min Li; Craig Weiss; John F. Disterhoft

doi:10.1002/1522-2594(200009)44:3<474::AID-MRM19>3.0.CO;2-I

fMRI of visual system activation in the conscious rabbit

Alice M. Wyrwicz, Nan Kuei Chen, Min Li, Craig Weiss, John F. Disterhoft

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A conscious rabbit preparation developed for fMRI, and the results from visual stimulation studies at a 4.7T magnetic field are described. The rabbit is ideal for these experiments because of its natural tolerance for restraint. High spatial and temporal resolution magnetic resonance images, without movement artifacts, were obtained during long periods of restraint. Functional activation in primary visual cortex and lateral geniculate nucleus (LGN) were reproducibly observed in response to light-stimulus. In comparison to existing anesthetized animal models, a functional response free of the anesthetic modulation can be recorded with the new approach. The conscious animal model can be applied to functional studies of sensory systems, learning and memory, and drug-induced cerebral activation. (C) 2000 Wiley-Liss, Inc.

Original language	English (US)
Pages (from-to)	474-478
Number of pages	5
Journal	Magnetic Resonance in Medicine
Volume	44
Issue number	3
DOIs	https://doi.org/10.1002/1522-2594(200009)44:3<474::AID-MRM19>3.0.CO;2-I
State	Published - 2000
Externally published	Yes

Keywords

BOLD
Conscious animal model
Functional activations
Visual cortex
fMRI

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/1522-2594(200009)44:3<474::AID-MRM19>3.0.CO;2-I

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AU - Chen, Nan Kuei

AU - Li, Min

AU - Weiss, Craig

AU - Disterhoft, John F.

PY - 2000

Y1 - 2000

N2 - A conscious rabbit preparation developed for fMRI, and the results from visual stimulation studies at a 4.7T magnetic field are described. The rabbit is ideal for these experiments because of its natural tolerance for restraint. High spatial and temporal resolution magnetic resonance images, without movement artifacts, were obtained during long periods of restraint. Functional activation in primary visual cortex and lateral geniculate nucleus (LGN) were reproducibly observed in response to light-stimulus. In comparison to existing anesthetized animal models, a functional response free of the anesthetic modulation can be recorded with the new approach. The conscious animal model can be applied to functional studies of sensory systems, learning and memory, and drug-induced cerebral activation. (C) 2000 Wiley-Liss, Inc.

AB - A conscious rabbit preparation developed for fMRI, and the results from visual stimulation studies at a 4.7T magnetic field are described. The rabbit is ideal for these experiments because of its natural tolerance for restraint. High spatial and temporal resolution magnetic resonance images, without movement artifacts, were obtained during long periods of restraint. Functional activation in primary visual cortex and lateral geniculate nucleus (LGN) were reproducibly observed in response to light-stimulus. In comparison to existing anesthetized animal models, a functional response free of the anesthetic modulation can be recorded with the new approach. The conscious animal model can be applied to functional studies of sensory systems, learning and memory, and drug-induced cerebral activation. (C) 2000 Wiley-Liss, Inc.

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KW - Functional activations

KW - Visual cortex

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fMRI of visual system activation in the conscious rabbit

Abstract

Keywords

ASJC Scopus subject areas

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