Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

R. Andrew Wall, Jennifer K. Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


A side-viewing, 2 mm diameter, surface magnifying chromoendoscopy (SMC)-optical coherence tomography (OCT) endoscope has been designed for simultaneous, non-destructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of mouse colon. A 30,000 element fiber bundle is combined with single mode fibers. The distal optics consist of a gradient-index lens and spacer to provide a magnification of 1 at a working distance of 1.58 mm in air, necessary to image the sample through a 0.23 mm thick outer glass envelope, and an aluminized right-angle prism fixed to the distal end of the GRIN lens assembly. The resulting 1:1 imaging system is capable of 3.9 μm lateral and 2.3 μm axial resolution in the OCT channel, and 125 lp/mm resolution across a 0.70 mm field of view in the SMC channel. The endoscope can perform high contrast crypt visualization, molecular imaging, and cross-sectional imaging of colon microstructure.

Original languageEnglish (US)
Title of host publicationEndoscopic Microscopy VII
StatePublished - 2012
EventEndoscopic Microscopy VII - San Francisco, CA, United States
Duration: Jan 22 2012Jan 23 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherEndoscopic Microscopy VII
Country/TerritoryUnited States
CitySan Francisco, CA


  • Aberrant crypt foci (ACF)
  • Catheter
  • Colon
  • Endoscope
  • Gastrointestinal (GI)
  • Gradient-index (GRIN)
  • Optical coherence tomography (OCT)
  • Surface magnifying chromoendoscopy (SMC)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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