TY - GEN
T1 - Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope
AU - Andrew Wall, R.
AU - Barton, Jennifer K.
PY - 2012
Y1 - 2012
N2 - A side-viewing, 2 mm diameter, surface magnifying chromoendoscopy (SMC)-optical coherence tomography (OCT) endoscope has been designed for simultaneous, non-destructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of mouse colon. A 30,000 element fiber bundle is combined with single mode fibers. The distal optics consist of a gradient-index lens and spacer to provide a magnification of 1 at a working distance of 1.58 mm in air, necessary to image the sample through a 0.23 mm thick outer glass envelope, and an aluminized right-angle prism fixed to the distal end of the GRIN lens assembly. The resulting 1:1 imaging system is capable of 3.9 μm lateral and 2.3 μm axial resolution in the OCT channel, and 125 lp/mm resolution across a 0.70 mm field of view in the SMC channel. The endoscope can perform high contrast crypt visualization, molecular imaging, and cross-sectional imaging of colon microstructure.
AB - A side-viewing, 2 mm diameter, surface magnifying chromoendoscopy (SMC)-optical coherence tomography (OCT) endoscope has been designed for simultaneous, non-destructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of mouse colon. A 30,000 element fiber bundle is combined with single mode fibers. The distal optics consist of a gradient-index lens and spacer to provide a magnification of 1 at a working distance of 1.58 mm in air, necessary to image the sample through a 0.23 mm thick outer glass envelope, and an aluminized right-angle prism fixed to the distal end of the GRIN lens assembly. The resulting 1:1 imaging system is capable of 3.9 μm lateral and 2.3 μm axial resolution in the OCT channel, and 125 lp/mm resolution across a 0.70 mm field of view in the SMC channel. The endoscope can perform high contrast crypt visualization, molecular imaging, and cross-sectional imaging of colon microstructure.
KW - Aberrant crypt foci (ACF)
KW - Catheter
KW - Colon
KW - Endoscope
KW - Gastrointestinal (GI)
KW - Gradient-index (GRIN)
KW - Optical coherence tomography (OCT)
KW - Surface magnifying chromoendoscopy (SMC)
UR - http://www.scopus.com/inward/record.url?scp=84858684887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858684887&partnerID=8YFLogxK
U2 - 10.1117/12.909291
DO - 10.1117/12.909291
M3 - Conference contribution
AN - SCOPUS:84858684887
SN - 9780819488602
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Endoscopic Microscopy VII
T2 - Endoscopic Microscopy VII
Y2 - 22 January 2012 through 23 January 2012
ER -