Flavonoids: From cell cycle regulation to biotechnology

Ho Hyung Woo, Byeong Ryong Jeong, Martha C. Hawes

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Flavonoids have been proposed to play diverse roles in plant growth and development, including defense, symbiosis, pollen development and male fertility, polar auxin transport, and protection against ultraviolet radiation. Recently, a new role in cell cycle regulation has emerged. Genetic alteration of glucuronide metabolism by altered expression of a Pisum sativum UDP-glucuronosyltransferase (PsUGT1) results in an altered cell cycle in pea, alfalfa, and Arabidopsis. In alfalfa, altered expression of PsUGT1 results in accumulation of a flavonoid-like compound that suppresses growth of cultured cells. The results are consistent with the hypothesis that PsUGT1 functions by controlling cellular levels of a factor controlling cell cycle (FCC).

Original languageEnglish (US)
Pages (from-to)365-374
Number of pages10
JournalBiotechnology Letters
Issue number6
StatePublished - Mar 2005


  • Cell cycle regulation
  • Flavonoids
  • UDP-glucuronosyltransferase

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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