@article{46b7f5a78a474023aa7e265c808fb0b1,
title = "Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21",
abstract = "Asthma affects nearly 14 million people worldwide and has been steadily increasing in frequency for the past 50 years. Although environmental factors clearly influence the onset, progression, and severity of this disease, family and twin studies indicate that genetic variation also influences susceptibility. Linkage of asthma and related phenotypes to chromosome 6p21 has been reported in seven genome screens, making it the most replicated region of the genome. However, because many genes with individually small effects are likely to contribute to risk, identification of asthma susceptibility loci has been challenging. In this study, we present evidence from four independent samples in support of HLA-G as a novel asthma and bronchial hyperresponsiveness susceptibility gene in the human leukocyte antigen region on chromosome 6p21, and we speculate that this gene might contribute to risk for other inflammatory diseases that show linkage to this region.",
author = "Dan Nicolae and Cox, {Nancy J.} and Lester, {Lucille A.} and Daniel Schneider and Zheng Tan and Christine Billstrand and Susan Kuldanek and Joseph Donfack and Paul Kogut and Patel, {Nina M.} and Jeffrey Goodenbour and Timothy Howard and Raoul Wolf and Koppelman, {Gerard H.} and White, {Steven R.} and Rodney Parry and Postma, {Dirkje S.} and Deborah Meyers and Bleecker, {Eugene R.} and Hunt, {Joan S.} and Julian Solway and Carole Ober",
note = "Funding Information: We acknowledge the following individuals and organizations: our CSGA collaborators (Malcolm Blumenthal, David Marsh, Terri Beaty, and Susan Banks-Schlegel); Rhonda Peterson, Jennifer Anderson, Heidi Gidley, Stephanie Willadsen, Patrick Klimczyk, Rebecca Brown, and Natasha Phillips, for coordinating the study and enrolling families in Chicago; Rhonda Morse and Vera Braun, for assistance on Hutterite field trips; Sue Platt, April Chan, Raluca Nicolae, and Megan Burkart, for technical assistance; Harvey Dytch, for computer programming; Henry Ehrlich (Roche Molecular Systems), for providing HLA-A genotyping reagents; The University of Chicago General Clinical Research Center (National Institutes of Health [NIH] grant M01 RR00055); and the many families that participated in these studies. The studies of Chicago families and Hutterites were supported by the NIH (grants HL72414, HL66533, and HL56399) and the Mammalian Genotyping Service (Marshfield, WI). The Dutch family studies were supported by the Netherlands Asthma Foundation (grants AF 95.09 and AF 3.2.00.38) and the NIH (grant HL66393). ",
year = "2005",
month = feb,
doi = "10.1086/427763",
language = "English (US)",
volume = "76",
pages = "349--357",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "2",
}