Field-based multiplex and quantitative assay platforms for diagnostics

Srivatsa Venkatasubbarao; C. Edward Dixon; Russell Chipman; Axel Scherer; Manal Beshay; Lothar U. Kempen; Jai Ganesh Chandra Sekhar; Hong Yan; Ava Puccio; David Okonkwo; Stephen McClain; Noah Gilbert; Saurabh Vyawahare

doi:10.1117/12.886661

Field-based multiplex and quantitative assay platforms for diagnostics

Srivatsa Venkatasubbarao, C. Edward Dixon, Russell Chipman, Axel Scherer, Manal Beshay, Lothar U. Kempen, Jai Ganesh Chandra Sekhar, Hong Yan, Ava Puccio, David Okonkwo, Stephen McClain, Noah Gilbert, Saurabh Vyawahare

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

The U.S. military has a continued interest in the development of handheld, field-usable sensors and test kits for a variety of diagnostic applications, such as traumatic brain injury (TBI) and infectious diseases. Field-use presents unique challenges for biosensor design, both for the readout unit and for the biological assay platform. We have developed robust biosensor devices that offer ultra-high sensitivity and also meet field-use needs. The systems under development include a multiplexed quantitative lateral flow test strip for TBI diagnostics, a field test kit for the diagnosis of pathogens endemic to the Middle East, and a microfluidic assay platform with a label-free reader for performing complex biological automated assays in the field.

Original language	English (US)
Title of host publication	Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII
Publisher	SPIE
ISBN (Print)	9780819486035
DOIs	https://doi.org/10.1117/12.886661
State	Published - May 13 2011

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	8029
ISSN (Print)	0277-786X

Keywords

dipstick assay
field-based diagnostics
labelless detection
lateral flow immunoassay
lateral flow test strip
microfluidic chips
traumatic brain injury

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.886661

Cite this

Venkatasubbarao, S., Dixon, C. E., Chipman, R., Scherer, A., Beshay, M., Kempen, L. U., Chandra Sekhar, J. G., Yan, H., Puccio, A., Okonkwo, D., McClain, S., Gilbert, N., & Vyawahare, S. (2011). Field-based multiplex and quantitative assay platforms for diagnostics. In Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII Article 80290P (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8029). SPIE. https://doi.org/10.1117/12.886661

Field-based multiplex and quantitative assay platforms for diagnostics. / Venkatasubbarao, Srivatsa; Dixon, C. Edward; Chipman, Russell et al.
Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII. SPIE, 2011. 80290P (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8029).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Venkatasubbarao, S, Dixon, CE, Chipman, R, Scherer, A, Beshay, M, Kempen, LU, Chandra Sekhar, JG, Yan, H, Puccio, A, Okonkwo, D, McClain, S, Gilbert, N & Vyawahare, S 2011, Field-based multiplex and quantitative assay platforms for diagnostics. in Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII., 80290P, Proceedings of SPIE - The International Society for Optical Engineering, vol. 8029, SPIE. https://doi.org/10.1117/12.886661

Venkatasubbarao S, Dixon CE, Chipman R, Scherer A, Beshay M, Kempen LU et al. Field-based multiplex and quantitative assay platforms for diagnostics. In Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII. SPIE. 2011. 80290P. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.886661

Venkatasubbarao, Srivatsa ; Dixon, C. Edward ; Chipman, Russell et al. / Field-based multiplex and quantitative assay platforms for diagnostics. Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII. SPIE, 2011. (Proceedings of SPIE - The International Society for Optical Engineering).

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Field-based multiplex and quantitative assay platforms for diagnostics

Abstract

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Keywords

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