Fentanyl-related compounds and derivatives: Current status and future prospects for pharmaceutical applications

Ruben S. Vardanyan; Victor J. Hruby

doi:10.4155/fmc.13.215

Fentanyl-related compounds and derivatives: Current status and future prospects for pharmaceutical applications

Ruben S. Vardanyan, Victor J. Hruby

Chemistry and Biochemistry

Research output: Contribution to journal › Review article › peer-review

221 Scopus citations

Abstract

Fentanyl and its analogs have been mainstays for the treatment of severe to moderate pain for many years. In this review, we outline the structural and corresponding synthetic strategies that have been used to understand the structure-biological activity relationship in fentanyl-related compounds and derivatives and their biological activity profiles. We discuss how changes in the scaffold structure can change biological and pharmacological activities. Finally, recent efforts to design and synthesize novel multivalent ligands that act as mu and delta opioid receptors and NK-1 receptors are discussed.

Original language	English (US)
Pages (from-to)	385-412
Number of pages	28
Journal	Future Medicinal Chemistry
Volume	6
Issue number	4
DOIs	https://doi.org/10.4155/fmc.13.215
State	Published - Mar 2014

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

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abstract = "Fentanyl and its analogs have been mainstays for the treatment of severe to moderate pain for many years. In this review, we outline the structural and corresponding synthetic strategies that have been used to understand the structure-biological activity relationship in fentanyl-related compounds and derivatives and their biological activity profiles. We discuss how changes in the scaffold structure can change biological and pharmacological activities. Finally, recent efforts to design and synthesize novel multivalent ligands that act as mu and delta opioid receptors and NK-1 receptors are discussed.",

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AB - Fentanyl and its analogs have been mainstays for the treatment of severe to moderate pain for many years. In this review, we outline the structural and corresponding synthetic strategies that have been used to understand the structure-biological activity relationship in fentanyl-related compounds and derivatives and their biological activity profiles. We discuss how changes in the scaffold structure can change biological and pharmacological activities. Finally, recent efforts to design and synthesize novel multivalent ligands that act as mu and delta opioid receptors and NK-1 receptors are discussed.

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Fentanyl-related compounds and derivatives: Current status and future prospects for pharmaceutical applications

Abstract

ASJC Scopus subject areas

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