FeCl3-catalyzed selective acylation of amines with 1,3-diketones via C-C bond cleavage

Sinan Wang, Yang Yu, Xuyun Chen, Haipan Zhu, Peile Du, Guohua Liu, Liguang Lou, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We describe a novel FeCl3 catalyzed selective acylation of amines involving the C-C bond cleavage of simple 1,3-diketones. The process proceeds efficiently under a neat condition to give structurally diverse amides. Notably, the acylation process displays high selectivity toward amines over hydroxyl functionality. Traditionally difficult aromatic amines and sterically demanding disubstituted amines can engage in the process with high efficiency.

Original languageEnglish (US)
Pages (from-to)3093-3096
Number of pages4
JournalTetrahedron Letters
Volume56
Issue number23
DOIs
StatePublished - May 25 2015
Externally publishedYes

Keywords

  • 1,3-Diketones
  • Acylation
  • C-C bond cleavage
  • FeCl

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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