Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy

Nam P. Nguyen; Shane P. Krafft; Paul Vos; Vincent Vinh-Hung; Misty Ceizyk; Siyoung Jang; Anand Desai; Dave Abraham; Lars Ewell; Christopher Watchman; Russ Hamilton; Beng Hoey Jo; Ulf Karlsson; Lexie Smith-Raymond

doi:10.1007/s00066-011-2220-z

Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy

Nam P. Nguyen, Shane P. Krafft, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Siyoung Jang, Anand Desai, Dave Abraham, Lars Ewell, Christopher Watchman, Russ Hamilton, Beng Hoey Jo, Ulf Karlsson, Lexie Smith-Raymond

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

To compare the dosimetry of tomotherapy and the conventional half-beam technique (HBT) or non-split beam technique (NSBT) for target coverage and radiation dose to the lacrimal glands and lens. Patients and Methods: A retrospective review of 7 patients with Graves' ophthalmopathy who had radiotherapy because of disease progression on high steroid dose is reported: 3 patients were treated with tomotherapy and 4 patients with HBT. Results: Compared to HBT, tomotherapy may provide better target coverage and significant reduction of radiation dose to the lacrimal glands and a higher dose to the lens. The NSBT improved target coverage but resulted in significantly higher doses to the lens and lacrimal glands. Conclusion: Tomotherapy may provide better coverage of the target volume and may be more effective in reducing severe exophthalmos compared to the conventional radiotherapy technique.

Original language	English (US)
Pages (from-to)	568-574
Number of pages	7
Journal	Strahlentherapie und Onkologie
Volume	187
Issue number	9
DOIs	https://doi.org/10.1007/s00066-011-2220-z
State	Published - Sep 2011

Keywords

Graves exophthalmos
Target coverage
Tomotherapy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Oncology

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10.1007/s00066-011-2220-z

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Nguyen, N. P., Krafft, S. P., Vos, P., Vinh-Hung, V., Ceizyk, M., Jang, S., Desai, A., Abraham, D., Ewell, L., Watchman, C., Hamilton, R., Jo, B. H., Karlsson, U., & Smith-Raymond, L. (2011). Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy. Strahlentherapie und Onkologie, 187(9), 568-574. https://doi.org/10.1007/s00066-011-2220-z

Nguyen, NP, Krafft, SP, Vos, P, Vinh-Hung, V, Ceizyk, M, Jang, S, Desai, A, Abraham, D, Ewell, L, Watchman, C, Hamilton, R, Jo, BH, Karlsson, U & Smith-Raymond, L 2011, 'Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy', Strahlentherapie und Onkologie, vol. 187, no. 9, pp. 568-574. https://doi.org/10.1007/s00066-011-2220-z

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abstract = "To compare the dosimetry of tomotherapy and the conventional half-beam technique (HBT) or non-split beam technique (NSBT) for target coverage and radiation dose to the lacrimal glands and lens. Patients and Methods: A retrospective review of 7 patients with Graves' ophthalmopathy who had radiotherapy because of disease progression on high steroid dose is reported: 3 patients were treated with tomotherapy and 4 patients with HBT. Results: Compared to HBT, tomotherapy may provide better target coverage and significant reduction of radiation dose to the lacrimal glands and a higher dose to the lens. The NSBT improved target coverage but resulted in significantly higher doses to the lens and lacrimal glands. Conclusion: Tomotherapy may provide better coverage of the target volume and may be more effective in reducing severe exophthalmos compared to the conventional radiotherapy technique.",

keywords = "Graves exophthalmos, Target coverage, Tomotherapy",

author = "Nguyen, {Nam P.} and Krafft, {Shane P.} and Paul Vos and Vincent Vinh-Hung and Misty Ceizyk and Siyoung Jang and Anand Desai and Dave Abraham and Lars Ewell and Christopher Watchman and Russ Hamilton and Jo, {Beng Hoey} and Ulf Karlsson and Lexie Smith-Raymond",

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doi = "10.1007/s00066-011-2220-z",

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AU - Ceizyk, Misty

AU - Jang, Siyoung

AU - Desai, Anand

AU - Abraham, Dave

AU - Ewell, Lars

AU - Watchman, Christopher

AU - Hamilton, Russ

AU - Jo, Beng Hoey

AU - Karlsson, Ulf

AU - Smith-Raymond, Lexie

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KW - Target coverage

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Feasibility of tomotherapy for Graves' ophthalmopathy dosimetry comparison with conventional radiotherapy

Abstract

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