Fate of therapy failures in adult idiopathic thrombocytopenic purpura

Vincent J. Picozzi, William R. Roeske, William P. Creger

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Of 38 adult patients with idiopathic thrombocytopenic purpura followed an average of more than 12 years, 15 suffered splenectomy failure or postsplenectomy recurrence of thrombocytopenia. Nine of the 15 also received immunosuppressive agents, and four of the nine failed such therapy. In eight of these 15 treatment failures normal or safe platelet counts were achieved in a subsequent three to 12 year period during which they received no therapy. The frequency of spontaneous recovery of satisfactory platelet levels in adults with idiopathic thrombocytopenic purpura in whom treatment failed may have negative implications for very vigorous or longstanding immunosuppressive therapeutic attempts in certain cases.

Original languageEnglish (US)
Pages (from-to)690-694
Number of pages5
JournalAmerican Journal of Medicine
Issue number5
StatePublished - 1980

ASJC Scopus subject areas

  • General Medicine


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