Familial aggregation of sinonasal polyps correlates with severity of disease

Noam A. Cohen; Jeffrey S. Widelitz; Alexander G. Chiu; James N. Palmer; David W. Kennedy

doi:10.1016/j.otohns.2005.11.042

Familial aggregation of sinonasal polyps correlates with severity of disease

Noam A. Cohen
, Jeffrey S. Widelitz
, Alexander G. Chiu
, James N. Palmer
, David W. Kennedy

Surgery

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

OBJECTIVE: Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP. STUDY DESIGN AND SETTING: A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance). RESULTS: Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs. CONCLUSIONS: Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity. EBM rating: B-2b

Original language	English (US)
Pages (from-to)	601-604
Number of pages	4
Journal	Otolaryngology - Head and Neck Surgery
Volume	134
Issue number	4
DOIs	https://doi.org/10.1016/j.otohns.2005.11.042
State	Published - Apr 2006

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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10.1016/j.otohns.2005.11.042

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title = "Familial aggregation of sinonasal polyps correlates with severity of disease",

abstract = "OBJECTIVE: Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP. STUDY DESIGN AND SETTING: A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance). RESULTS: Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs. CONCLUSIONS: Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity. EBM rating: B-2b",

author = "Cohen, \{Noam A.\} and Widelitz, \{Jeffrey S.\} and Chiu, \{Alexander G.\} and Palmer, \{James N.\} and Kennedy, \{David W.\}",

note = "Funding Information: Supported by the American Academy of Otolaryngic Allergy. ",

year = "2006",

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doi = "10.1016/j.otohns.2005.11.042",

language = "English (US)",

volume = "134",

pages = "601--604",

journal = "Otolaryngology - Head and Neck Surgery",

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T1 - Familial aggregation of sinonasal polyps correlates with severity of disease

AU - Cohen, Noam A.

AU - Widelitz, Jeffrey S.

AU - Chiu, Alexander G.

AU - Palmer, James N.

AU - Kennedy, David W.

N1 - Funding Information: Supported by the American Academy of Otolaryngic Allergy.

PY - 2006/4

Y1 - 2006/4

N2 - OBJECTIVE: Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP. STUDY DESIGN AND SETTING: A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance). RESULTS: Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs. CONCLUSIONS: Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity. EBM rating: B-2b

AB - OBJECTIVE: Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP. STUDY DESIGN AND SETTING: A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance). RESULTS: Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs. CONCLUSIONS: Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity. EBM rating: B-2b

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SN - 0194-5998

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JO - Otolaryngology - Head and Neck Surgery

JF - Otolaryngology - Head and Neck Surgery

IS - 4

ER -

Familial aggregation of sinonasal polyps correlates with severity of disease

Abstract

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