TY - JOUR
T1 - Familial aggregation of sinonasal polyps correlates with severity of disease
AU - Cohen, Noam A.
AU - Widelitz, Jeffrey S.
AU - Chiu, Alexander G.
AU - Palmer, James N.
AU - Kennedy, David W.
N1 - Funding Information:
Supported by the American Academy of Otolaryngic Allergy.
PY - 2006/4
Y1 - 2006/4
N2 - OBJECTIVE: Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP. STUDY DESIGN AND SETTING: A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance). RESULTS: Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs. CONCLUSIONS: Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity. EBM rating: B-2b
AB - OBJECTIVE: Investigate familial aggregation of sinonasal polyps (NP) and correlate the severity of chronic rhinosinusitis (CRS) with a family history of NP. STUDY DESIGN AND SETTING: A questionnaire documenting NP, asthma, or aspirin intolerance was completed by 174 CRS patients. Severity of sinus disease was stratified as isolated NP, NP with concomitant asthma, and Samter's triad (polyps, asthma, and aspirin intolerance). RESULTS: Compared to controls, CRS patients had a higher incidence of a family history of NP. Additionally, patients stratified with severe CRS had a higher incidence of relatives with NPs. CONCLUSIONS: Familial aggregation of NP is demonstrated in CRS patients and correlates with disease severity. EBM rating: B-2b
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U2 - 10.1016/j.otohns.2005.11.042
DO - 10.1016/j.otohns.2005.11.042
M3 - Article
C2 - 16564380
AN - SCOPUS:33645278974
SN - 0194-5998
VL - 134
SP - 601
EP - 604
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 4
ER -