TY - JOUR
T1 - Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer
AU - Liu, Pengyuan
AU - Vikis, Haris G.
AU - Wang, Daolong
AU - Lu, Yan
AU - Wang, Yian
AU - Schwartz, Ann G.
AU - Pinney, Susan M.
AU - Yang, Ping
AU - De Andrade, Mariza
AU - Petersen, Gloria M.
AU - Wiest, Jonathan S.
AU - Fain, Pamela R.
AU - Gazdar, Adi
AU - Gaba, Colette
AU - Rothschild, Henry
AU - Mandal, Diptasri
AU - Coons, Teresa
AU - Lee, Juwon
AU - Kupert, Elena
AU - Seminara, Daniela
AU - Minna, John
AU - Bailey-Wilson, Joan E.
AU - Wu, Xifeng
AU - Spitz, Margaret R.
AU - Eisen, Timothy
AU - Houlston, Richard S.
AU - Amos, Christopher I.
AU - Anderson, Marshall W.
AU - You, Ming
PY - 2008/9
Y1 - 2008/9
N2 - Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.
AB - Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.
UR - https://www.scopus.com/pages/publications/52449127998
UR - https://www.scopus.com/pages/publications/52449127998#tab=citedBy
U2 - 10.1093/jnci/djn268
DO - 10.1093/jnci/djn268
M3 - Article
C2 - 18780872
AN - SCOPUS:52449127998
SN - 0027-8874
VL - 100
SP - 1326
EP - 1330
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 18
ER -