Abstract
The first direct enantioselective FriedelCrafts reaction of indoles with isatins has been developed. The process is catalyzed by simple cupreine under mild reaction conditions and affords synthetically and biologically interesting, chiral 3-indolyl-3-hydroxy-2-oxindoles in good yields (6897%) and with high enantioselectivities (76-91%).
Original language | English (US) |
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Pages (from-to) | 833-838 |
Number of pages | 6 |
Journal | Advanced Synthesis and Catalysis |
Volume | 352 |
Issue number | 5 |
DOIs | |
State | Published - Mar 22 2010 |
Externally published | Yes |
Keywords
- Asymmetric friedel-crafts reaction
- Indoles
- Isatins
- Organocatalysis
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry