Facile construction of pyrrolo[1,2-: B] isoquinolin-10(5 H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors

Shanchao Wu, Na Liu, Guoqiang Dong, Lin Ma, Shengzheng Wang, Wencai Shi, Kun Fang, Shuqiang Chen, Jian Li, Wannian Zhang, Chunquan Sheng, Wei Wang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

An efficient redox-amination-aromatization-Friedel-Crafts acylation cascade process from trans-4-hydroxyproline and 2-formylbenzoic acids has been developed for the synthesis of pyrrolo[1,2-b]isoquinolin-10(5H)-ones. Compound 3h was identified as a new potent dual topoisomerase I/II inhibitor.

Original languageEnglish (US)
Pages (from-to)9593-9596
Number of pages4
JournalChemical Communications
Volume52
Issue number61
DOIs
StatePublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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