Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective michael-michael cascade

Shengzheng Wang; Yongqiang Zhang; Guoqiang Dong; Shanchao Wu; Kun Fang; Zhengang Li; Zhenyuan Miao; Jianzhong Yao; Hao Li; Jian Li; Wannian Zhang; Wei Wang; Chunquan Sheng

doi:10.1021/ol4033557

Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective michael-michael cascade

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, Shanchao Wu, Kun Fang, Zhengang Li, Zhenyuan Miao, Jianzhong Yao, Hao Li, Jian Li, Wannian Zhang, Wei Wang, Chunquan Sheng

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

An organocatalytic enantioselective Michael-Michael cascade reaction has been implemented for the creation of structurally variant chiral tetrahydrothiopyrans. The process is realized by employment of new bifunctional ketothioether enones and proceeds highly enantioselectively with formation of four consecutive stereogenic centers.

Original language	English (US)
Pages (from-to)	692-695
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	3
DOIs	https://doi.org/10.1021/ol4033557
State	Published - Feb 7 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol4033557

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title = "Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective michael-michael cascade",

abstract = "An organocatalytic enantioselective Michael-Michael cascade reaction has been implemented for the creation of structurally variant chiral tetrahydrothiopyrans. The process is realized by employment of new bifunctional ketothioether enones and proceeds highly enantioselectively with formation of four consecutive stereogenic centers.",

author = "Shengzheng Wang and Yongqiang Zhang and Guoqiang Dong and Shanchao Wu and Kun Fang and Zhengang Li and Zhenyuan Miao and Jianzhong Yao and Hao Li and Jian Li and Wannian Zhang and Wei Wang and Chunquan Sheng",

year = "2014",

month = feb,

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doi = "10.1021/ol4033557",

language = "English (US)",

volume = "16",

pages = "692--695",

journal = "Organic Letters",

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TY - JOUR

T1 - Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective michael-michael cascade

AU - Wang, Shengzheng

AU - Zhang, Yongqiang

AU - Dong, Guoqiang

AU - Wu, Shanchao

AU - Fang, Kun

AU - Li, Zhengang

AU - Miao, Zhenyuan

AU - Yao, Jianzhong

AU - Li, Hao

AU - Li, Jian

AU - Zhang, Wannian

AU - Wang, Wei

AU - Sheng, Chunquan

PY - 2014/2/7

Y1 - 2014/2/7

N2 - An organocatalytic enantioselective Michael-Michael cascade reaction has been implemented for the creation of structurally variant chiral tetrahydrothiopyrans. The process is realized by employment of new bifunctional ketothioether enones and proceeds highly enantioselectively with formation of four consecutive stereogenic centers.

AB - An organocatalytic enantioselective Michael-Michael cascade reaction has been implemented for the creation of structurally variant chiral tetrahydrothiopyrans. The process is realized by employment of new bifunctional ketothioether enones and proceeds highly enantioselectively with formation of four consecutive stereogenic centers.

UR - http://www.scopus.com/inward/record.url?scp=84893821566&partnerID=8YFLogxK

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U2 - 10.1021/ol4033557

DO - 10.1021/ol4033557

M3 - Article

C2 - 24437648

AN - SCOPUS:84893821566

SN - 1523-7060

VL - 16

SP - 692

EP - 695

JO - Organic Letters

JF - Organic Letters

IS - 3

ER -

Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective michael-michael cascade

Abstract

ASJC Scopus subject areas

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