Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective michael-michael cascade

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, Shanchao Wu, Kun Fang, Zhengang Li, Zhenyuan Miao, Jianzhong Yao, Hao Li, Jian Li, Wannian Zhang, Wei Wang, Chunquan Sheng

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

An organocatalytic enantioselective Michael-Michael cascade reaction has been implemented for the creation of structurally variant chiral tetrahydrothiopyrans. The process is realized by employment of new bifunctional ketothioether enones and proceeds highly enantioselectively with formation of four consecutive stereogenic centers.

Original languageEnglish (US)
Pages (from-to)692-695
Number of pages4
JournalOrganic Letters
Volume16
Issue number3
DOIs
StatePublished - Feb 7 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective michael-michael cascade'. Together they form a unique fingerprint.

Cite this