Relapse of acute lymphoblastic leukemia (ALL) in the breast is uncommon and often precedes systemic relapse, resulting in poor survival. We report the development of breast involvement of ALL in a 20-year-old woman 32 months after a related allogeneic peripheral blood hematopoietic cell transplantation (PBHCT) in first remission. This extramedullary relapse occurred in the continuous presence of complete donor chimerism. After systemic re-induction chemotherapy and a second PBHCT using donor cells that had been cryopreserved at first transplant, our patient has remained in second complete remission for more than 44 months.
- Acute lymphoblastic leukemia
- Allogeneic peripheral blood stem cell transplant
- Extramedullary breast relapse
- Graft-versus-host disease
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health