Expression of the Wnt inhibitor, sFRP5, in the gut endoderm of Xenopus

Karen E. Pilcher, Paul A. Krieg

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Signaling by the Wnt family of secreted growth factors is involved in numerous different aspects of embryonic development and also for maintenance of cellular function in adult tissues. In addition to regulation at the transcriptional level, Wnt activity is modulated by a number of different Wnt-binding proteins. Here we report the cloning and developmental expression pattern of the Xenopus orthologue of secreted Frizzled-related protein 5 (sFRP5), an endogenous inhibitor of Wnt signaling. At early stages of endodermal differentiation, sFRP5 is expressed in the developing liver. At later stages however, sFRP5 expression is down-regulated in the liver and becomes strongly expressed in the region corresponding to the junction between the posterior portion of the stomach and the anterior intestines.

Original languageEnglish (US)
Pages (from-to)369-372
Number of pages4
JournalGene Expression Patterns
Issue number3-4
StatePublished - Dec 2002


  • Endoderm
  • Frizzled-related protein
  • Intestines
  • Liver
  • Stomach
  • Xenopus
  • sFRP5

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology


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