Expression of atrial natriuretic factor (ANF) during Xenopus cardiac development

E. M. Small, P. A. Krieg

Research output: Contribution to journalComment/debatepeer-review

25 Scopus citations


We have isolated the Xenopus orthologue of the atrial natriuretic factor (ANF) gene. Characterization of embryonic expression indicates that the ANF gene is initially expressed throughout the developing myocardium at the late heart tube stage (about stage 32). This is in contrast to all previously characterized Xenopus cardiac differentiation markers that are first expressed in the cardiogenic plate at approximately stage 27. ANF expression becomes restricted exclusively to the atrium at about stage 47, long after the commencement of beating and the original formation of the atrial and ventricular compartments, but shortly after septation of the single atrium into two distinct atria.

Original languageEnglish (US)
Pages (from-to)638-640
Number of pages3
JournalDevelopment Genes and Evolution
Issue number12
StatePublished - 2000
Externally publishedYes


  • Atrial natriuretic factor
  • Heart
  • Septation
  • Xenopus laevis

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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