Expression of a novel function-associated molecule on cells mediating spontaneous cytolysis in swine

Todd D. Camenisch; Liliana Jaso-Friedmann; Donald L. Evans; David T. Harris

doi:10.1016/0145-305X(93)90046-S

Expression of a novel function-associated molecule on cells mediating spontaneous cytolysis in swine

Todd D. Camenisch, Liliana Jaso-Friedmann, Donald L. Evans, David T. Harris

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In the present study, we have analyzed the effects of the anti-FAM mAb 5C6, on endogenous NK cell and lymphokineactivated killer (LAK) cell activity of swine. We report that the anti-FAM mAb 5C6 binds to fresh and cultured lymphocytes with spontaneous cytotoxic activity from swine peripheral blood. In conjunction, the anti-FAM mAb 5C6 inhibits swine cytolysis against K562 target cells. Inhibition was found to be mediated by blocking of conjugate formation. The level of spontaneous killing and mAb inhibition was correlated with the number of swine cells staining positive with the mAb 5C6 as assessed by flow cytometry.

Original language	English (US)
Pages (from-to)	277-282
Number of pages	6
Journal	Developmental and Comparative Immunology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0145-305X(93)90046-S
State	Published - 1993

Keywords

Function-associated molecule
Natural killer
Nonspecific immunity
Spontaneous cytotoxicity
Swine lymphocytes

ASJC Scopus subject areas

Immunology
Developmental Biology

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title = "Expression of a novel function-associated molecule on cells mediating spontaneous cytolysis in swine",

abstract = "In the present study, we have analyzed the effects of the anti-FAM mAb 5C6, on endogenous NK cell and lymphokineactivated killer (LAK) cell activity of swine. We report that the anti-FAM mAb 5C6 binds to fresh and cultured lymphocytes with spontaneous cytotoxic activity from swine peripheral blood. In conjunction, the anti-FAM mAb 5C6 inhibits swine cytolysis against K562 target cells. Inhibition was found to be mediated by blocking of conjugate formation. The level of spontaneous killing and mAb inhibition was correlated with the number of swine cells staining positive with the mAb 5C6 as assessed by flow cytometry.",

keywords = "Function-associated molecule, Natural killer, Nonspecific immunity, Spontaneous cytotoxicity, Swine lymphocytes",

author = "Camenisch, \{Todd D.\} and Liliana Jaso-Friedmann and Evans, \{Donald L.\} and Harris, \{David T.\}",

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doi = "10.1016/0145-305X(93)90046-S",

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T1 - Expression of a novel function-associated molecule on cells mediating spontaneous cytolysis in swine

AU - Camenisch, Todd D.

AU - Jaso-Friedmann, Liliana

AU - Evans, Donald L.

AU - Harris, David T.

PY - 1993

Y1 - 1993

N2 - In the present study, we have analyzed the effects of the anti-FAM mAb 5C6, on endogenous NK cell and lymphokineactivated killer (LAK) cell activity of swine. We report that the anti-FAM mAb 5C6 binds to fresh and cultured lymphocytes with spontaneous cytotoxic activity from swine peripheral blood. In conjunction, the anti-FAM mAb 5C6 inhibits swine cytolysis against K562 target cells. Inhibition was found to be mediated by blocking of conjugate formation. The level of spontaneous killing and mAb inhibition was correlated with the number of swine cells staining positive with the mAb 5C6 as assessed by flow cytometry.

AB - In the present study, we have analyzed the effects of the anti-FAM mAb 5C6, on endogenous NK cell and lymphokineactivated killer (LAK) cell activity of swine. We report that the anti-FAM mAb 5C6 binds to fresh and cultured lymphocytes with spontaneous cytotoxic activity from swine peripheral blood. In conjunction, the anti-FAM mAb 5C6 inhibits swine cytolysis against K562 target cells. Inhibition was found to be mediated by blocking of conjugate formation. The level of spontaneous killing and mAb inhibition was correlated with the number of swine cells staining positive with the mAb 5C6 as assessed by flow cytometry.

KW - Function-associated molecule

KW - Natural killer

KW - Nonspecific immunity

KW - Spontaneous cytotoxicity

KW - Swine lymphocytes

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AN - SCOPUS:0027325330

SN - 0145-305X

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JO - Developmental and Comparative Immunology

JF - Developmental and Comparative Immunology

IS - 3

ER -

Expression of a novel function-associated molecule on cells mediating spontaneous cytolysis in swine

Abstract

Keywords

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