TY - JOUR
T1 - Exposure to Diabetes in Utero Is Associated with Earlier Pubertal Timing and Faster Pubertal Growth in the Offspring
T2 - The EPOCH Study
AU - Hockett, Christine W.
AU - Bedrick, Edward J.
AU - Zeitler, Philip
AU - Crume, Tessa L.
AU - Daniels, Stephen
AU - Dabelea, Dana
N1 - Funding Information:
Supported by the National Institute of Health , National Institute of Diabetes, Digestive, and Kidney Diseases ( R01 DK068001 ). Its contents are the authors' sole responsibility and do not necessarily represent official NIH views. The funders had no role in the design, conduct, or reporting of this work. The authors declare no conflicts of interest.
Funding Information:
Supported by the National Institute of Health, National Institute of Diabetes, Digestive, and Kidney Diseases (R01 DK068001). Its contents are the authors? sole responsibility and do not necessarily represent official NIH views. The funders had no role in the design, conduct, or reporting of this work. The authors declare no conflicts of interest.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/3
Y1 - 2019/3
N2 - Objective: To examine the associations of in utero exposure to maternal diabetes with surrogate measures of offspring pubertal timing (age at peak height velocity [APHV]) and speed of pubertal growth (peak height velocity [PHV]). Study design: Data from 77 exposed and 340 unexposed youth followed from age 2 to 19 years (51% non-Hispanic white, 50% female) were analyzed using the Exploring Perinatal Outcomes among Children study, a historical prospective cohort. Maternal diabetes status was collected from obstetric records, and child heights from 2 years to current age from pediatric records. Other covariates were collected during research visits. The superimposition by translation and rotation method, using height measurements (4-52 per participant), modeled APHV and PHV. Accelerated failure time analyses were used to test whether exposure to maternal diabetes was associated with younger APHV and faster PHV. Results: Adjusting for child's sex, race/ethnicity, and socioeconomic status, median APHV was reached ~3 months earlier in youth exposed to maternal diabetes compared with unexposed youth (P <.03). Youth exposed to maternal diabetes had a faster PHV than unexposed youth: exposed girls had 10.5% greater median PHV compared with unexposed girls and exposed boys had a 4.0% greater median PHV compared with unexposed boys (P <.001 for exposure by sex interaction). Conclusions: Our findings provide evidence that exposure to maternal diabetes in utero is associated with earlier pubertal timing and faster pubertal growth. Whether earlier puberty or faster speed of pubertal growth mediates the association between maternal diabetes exposure and later chronic disease risk remains to be studied.
AB - Objective: To examine the associations of in utero exposure to maternal diabetes with surrogate measures of offspring pubertal timing (age at peak height velocity [APHV]) and speed of pubertal growth (peak height velocity [PHV]). Study design: Data from 77 exposed and 340 unexposed youth followed from age 2 to 19 years (51% non-Hispanic white, 50% female) were analyzed using the Exploring Perinatal Outcomes among Children study, a historical prospective cohort. Maternal diabetes status was collected from obstetric records, and child heights from 2 years to current age from pediatric records. Other covariates were collected during research visits. The superimposition by translation and rotation method, using height measurements (4-52 per participant), modeled APHV and PHV. Accelerated failure time analyses were used to test whether exposure to maternal diabetes was associated with younger APHV and faster PHV. Results: Adjusting for child's sex, race/ethnicity, and socioeconomic status, median APHV was reached ~3 months earlier in youth exposed to maternal diabetes compared with unexposed youth (P <.03). Youth exposed to maternal diabetes had a faster PHV than unexposed youth: exposed girls had 10.5% greater median PHV compared with unexposed girls and exposed boys had a 4.0% greater median PHV compared with unexposed boys (P <.001 for exposure by sex interaction). Conclusions: Our findings provide evidence that exposure to maternal diabetes in utero is associated with earlier pubertal timing and faster pubertal growth. Whether earlier puberty or faster speed of pubertal growth mediates the association between maternal diabetes exposure and later chronic disease risk remains to be studied.
KW - SITAR
KW - age at peak height velocity
KW - lifecourse epidemiology
KW - peak height velocity
KW - perinatal exposure
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U2 - 10.1016/j.jpeds.2018.10.053
DO - 10.1016/j.jpeds.2018.10.053
M3 - Article
C2 - 30528762
AN - SCOPUS:85057629578
SN - 0022-3476
VL - 206
SP - 105
EP - 112
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -