Exposure assessment in the National Children's Study: Introduction

Larry L. Needham, Halûk Özkaynak, Robin M. Whyatt, Dana B. Barr, Richard Y. Wang, Luke Naeher, Gerry Akland, Tina Bahadori, Asa Bradman, Roy Fortmann, L. J.Sally Liu, Maria Morandi, Mary Kay O'Rourke, Kent Thomas, James Quackenboss, P. Barry Ryan, Valerie Zartarian

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


The science of exposure assessment is relatively new and evolving rapidly with the advancement of sophisticated methods for specific measurements at the picogram per gram level or lower in a variety of environmental and biologic matrices. Without this measurement capability, environmental health studies rely on questionnaires or other indirect means as the primary method to assess individual exposures. Although we use indirect methods, they are seldom used as stand-alone tools. Analyses of environmental and biologic samples have allowed us to get more precise data on exposure pathways, from sources to concentrations, to routes, to exposure, to doses. They also often allow a better estimation of the absorbed dose and its relation to potential adverse health outcomes in individuals and in populations. Here, we make note of various environmental agents and how best to assess exposure to them in the National Children's Study - a longitudinal epidemiologic study of children's health. Criteria for the analytical method of choice are discussed with particular emphasis on the need for long-term quality control and quality assurance measures.

Original languageEnglish (US)
Pages (from-to)1076-1082
Number of pages7
JournalEnvironmental health perspectives
Issue number8
StatePublished - Aug 2005


  • Biomonitoring
  • Environmental monitoring questionnaire
  • Exposure assessment
  • Limit of detection
  • National children's study

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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