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Exploring simple independent action in multifactor tables of proportions

  • W. W. Piegorsch
  • , C. R. Weinberg
  • , B. H. Margolin

Research output: Contribution to journalArticlepeer-review

Abstract

The problem of assessing synergistic or antagonistic departure from simple independent action in multifactor tables of proportions is discussed. A generalized linear model is employed in which additivity corresponds to simple independent action. Data-analytic strategies are proposed for exploring departures from simple independent action in various extensions of the 2 x 2 table of proportions. This methodology is illustrated with a series of models fitted to cellular differentiation and murine toxicity data.

Original languageEnglish (US)
Pages (from-to)595-603
Number of pages9
JournalBiometrics
Volume44
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences
  • Applied Mathematics

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