Abstract
An isocyanide-based multicomponent reaction (IMCR) utilized for the rapid assembly of novel, biologically relevant dihydropyrrolo[1,2-a]quinoxalines- amidines is herein presented. Starting from 1-(2-aminophenyl)pyrroles, aldehydes, and isonitriles, the target heterocyclic scaffold is assembled in a one-pot, operationally friendly process. With three points of diversity and formation of three chemical bonds in one step, this strategy proves to be very general. Novel, mild methodology for the generation of amidines from secondary amine anilines and isonitriles is also introduced.
Original language | English (US) |
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Pages (from-to) | 3328-3331 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 55 |
Issue number | 22 |
DOIs | |
State | Published - May 28 2014 |
Keywords
- Amidine
- Isonitrile
- Multicomponent reaction
- Pictet-Spengler
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry