@article{9cf512868fe246ef8dba4f2cd84d4b36,
title = "Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function",
abstract = "The use of animal models in brain aging research has led to numerous fundamental insights into the neurobiological processes that underlie changes in brain function associated with normative aging. Macaque monkeys have become the predominant nonhuman primate model system in brain aging research due to their striking similarities to humans in their behavioral capacities, sensory processing abilities, and brain architecture. Recent public concern about nonhuman primate research has made it imperative to attempt to clearly articulate the potential benefits to human health that this model enables. The present review will highlight how nonhuman primates provide a critical bridge between experiments conducted in rodents and development of therapeutics for humans. Several studies discussed here exemplify how nonhuman primate research has enriched our understanding of cognitive and sensory decline in the aging brain, as well as how this work has been important for translating mechanistic implications derived from experiments conducted in rodents to human brain aging research.",
keywords = "Cognitive aging, Nonhuman primates, Presbycusis",
author = "Gray, {Daniel T.} and Barnes, {Carol A.}",
note = "Funding Information: ACKNOWLEDGMENTS. We thank Michelle Albert for assistance with the graphics. This work was supported by NIH Grants R01 AG050548 (to C.A.B.) and F31 AG055263 (to D.T.G.) and by the McKnight Brain Research Foundation. Funding Information: This paper results from the Arthur M. Sackler Colloquium of the National Academy of Sciences, “Using Monkey Models to Understand and Develop Treatments for Human Brain Disorders,” held January 7–8, 2019, at the Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering in Irvine, CA. NAS colloquia began in 1991 and have been published in PNAS since 1995. From February 2001 through May 2019 colloquia were supported by a generous gift from The Dame Jillian and Dr. Arthur M. Sackler Foundation for the Arts, Sciences, & Humanities, in memory of Dame Sackler{\textquoteright}s husband, Arthur M. Sackler. The complete program and video recordings of most presentations are available on the NAS website at http://www.nasonline.org/using-monkey-models. Publisher Copyright: {\textcopyright} 2019 National Academy of Sciences. All rights reserved.",
year = "2019",
month = dec,
day = "26",
doi = "10.1073/pnas.1902279116",
language = "English (US)",
volume = "116",
pages = "26247--26254",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "52",
}